Schechtman V L, Harper R K, Harper R M
Brain Research Institute, UCLA School of Medicine 90024-1761.
Sleep. 1994 Jun;17(4):316-22. doi: 10.1093/sleep/17.4.316.
Adults show distinctive patterns of slow-wave (delta) electroencephalogram (EEG) activity across each sleep cycle and across the night. We examined the ontogeny of slow-wave EEG patterning in infants. Twelve-hour overnight physiological recordings were obtained from 25 normal infants at 1 week and 1, 2, 3, 4 and 6 months of age. The EEG activity was band-pass filtered, leaving primarily activity ranging from 0.5 to 2.5 Hz (the delta frequency). Filtered EEG traces were full-wave rectified and integrated over 1-minute periods. Nighttime recordings were divided into four 3-hour segments, beginning at sleep onset, and the mean integrated delta activity during quiet sleep was determined for each segment of the night. In addition, patterns of delta activity across extended periods of quiet sleep (15 minutes or longer) were determined. Beginning at 2 months of age, integrated delta activity declined significantly over the night. Moreover, beginning at 3 months of age, delta activity increased significantly over individual periods of quiet sleep; in neonates up to 1 month of age, delta activity decreased significantly within epochs of quiet sleep. Beginning at 2-3 months of age, infants show patterns of delta activity similar to those found in adults.
成年人在每个睡眠周期以及整个夜间都表现出独特的慢波（δ）脑电图（EEG）活动模式。我们研究了婴儿慢波脑电图模式的个体发生情况。对25名1周龄以及1、2、3、4和6月龄的正常婴儿进行了为期12小时的夜间生理记录。对脑电图活动进行带通滤波，主要保留0.5至2.5赫兹（δ频率）范围内的活动。滤波后的脑电图轨迹进行全波整流，并在1分钟时间段内进行积分。夜间记录从睡眠开始起分为四个3小时时段，确定每个夜间时段安静睡眠期间的平均积分δ活动。此外，还确定了长时间安静睡眠（15分钟或更长时间）期间的δ活动模式。从2月龄开始，夜间积分δ活动显著下降。此外，从3月龄开始，在各个安静睡眠时段内δ活动显著增加；在1月龄及以内的新生儿中，安静睡眠期间δ活动显著减少。从2至3月龄开始，婴儿表现出与成年人相似的δ活动模式。
