Olsson R, Johansson C, Lindstedt G, Mellström D
Dept. of Internal Medicine, Sahlgrenska Hospital, Sweden.
Scand J Gastroenterol. 1994 Aug;29(8):753-6. doi: 10.3109/00365529409092505.
Data on risk factors for bone loss in chronic active hepatitis (CAH) and primary biliary cirrhosis (PBC) are scanty and/or conflicting.
Bone mineral density (BMD) in the distal forearm was measured using single-photon absorptiometry in 39 patients with CAH and 32 patients with PBC. We also attempted to identify risk factors for bone loss by means of a questionnaire and through a wide range of biochemical analyses.
In the CAH patients BMD is inversely related to the duration of steroid treatment and to age at menarche. In the PBC patients there was a strong correlation between BMD and serum gastrin concentrations.
Bone loss in CAH is to some extent explained by steroid treatment and delayed menarche. Bone loss in PBC may be reduced by increased calcitonin secretion induced by gastrocalcin.
关于慢性活动性肝炎（CAH）和原发性胆汁性肝硬化（PBC）骨丢失危险因素的数据很少且/或相互矛盾。
采用单光子吸收法测量了39例CAH患者和32例PBC患者前臂远端的骨矿物质密度（BMD）。我们还试图通过问卷调查和广泛的生化分析来确定骨丢失的危险因素。
在CAH患者中，BMD与类固醇治疗的持续时间和初潮年龄呈负相关。在PBC患者中，BMD与血清胃泌素浓度之间存在很强的相关性。
CAH中的骨丢失在一定程度上可由类固醇治疗和初潮延迟来解释。PBC中的骨丢失可能通过胃降钙素诱导的降钙素分泌增加而减少。
