Netscher D T, Wigoda P, Green L K, Spira M
Division of Plastic Surgery, Baylor College of Medicine, Houston, TX 77030.
South Med J. 1994 Dec;87(12):1272-6. doi: 10.1097/00007611-199412000-00013.
Although keratoacanthoma regresses spontaneously, treating physicians seldom allow these lesions to progress through their natural course. We describe two cases of skin lesions, the first being a keratoacanthoma, which enlarged rapidly and then involuted with minimal scarring. The second lesion was initially misdiagnosed and failed to respond to medical management. An accurate diagnosis of squamous cell carcinoma was not made until the lesion had become deeply invasive. These two lesions have helped clarify our thoughts about the observation of keratoacanthomas, the need for frequent patient follow-up when a lesion is not surgically ablated, and the importance of providing the pathologist with an adequate biopsy specimen for diagnostic purposes.
尽管角化棘皮瘤可自行消退，但治疗医生很少让这些病变自然发展。我们描述了两例皮肤病变，第一例是角化棘皮瘤，其迅速增大，然后消退，留下最小程度的疤痕。第二例病变最初被误诊，且对药物治疗无反应。直到病变出现深部浸润才准确诊断为鳞状细胞癌。这两例病变有助于我们明确对角化棘皮瘤观察的思路、当病变未手术切除时对患者进行频繁随访的必要性，以及为病理学家提供足够的活检标本用于诊断目的的重要性。
