De Keyser J, Wilczak N, De Backer J P, Herroelen L, Vauquelin G
Department of Neurology, Academisch Ziekenhuis, Vrije Universiteit Brussel, Belgium.
Synapse. 1994 Jul;17(3):196-202. doi: 10.1002/syn.890170309.
Insulin-like growth factor (IGF)-I receptors were studied in adult human postmortem brain and pituitary gland using quantitative autoradiography with human recombinant [125I]IGF-I. The highest densities were found in the choroid plexus, pituitary gland--where IGF-I receptors were mainly concentrated in the anterior lobe, pineal gland, glomerular layer of the olfactory bulb, and the molecular layer of the cerebellar cortex. Moderate densities were present in cerebral cortex, caudate nucleus, putamen, accumbens, the CA1, CA2, CA3 fields and dentate gyrus of the hippocampus, the dentate nucleus of the cerebellum, amygdala, thalamus, pontine nuclei, and substantia nigra. All other brain areas, including white matter, contained low densities of IGF-I receptors. The finding that several well-defined brain structures are enriched with IGF-I receptors suggests a neurotrophic/survival or neuromodulatory role of insulin-like growth factors on specific neuronal systems. IGF-I receptors observed in the white matter may be associated with oligodendrocytes.
使用重组人[125I]IGF-I通过定量放射自显影技术对成人尸检脑和垂体中的胰岛素样生长因子（IGF）-I受体进行了研究。在脉络丛、垂体（IGF-I受体主要集中在前叶）、松果体、嗅球的肾小球层和小脑皮质的分子层中发现了最高密度。在大脑皮质、尾状核、壳核、伏隔核、海马的CA1、CA2、CA3区和齿状回、小脑的齿状核、杏仁核、丘脑、脑桥核和黑质中存在中等密度。包括白质在内的所有其他脑区含有低密度的IGF-I受体。几个明确的脑结构富含IGF-I受体这一发现表明胰岛素样生长因子对特定神经元系统具有神经营养/存活或神经调节作用。在白质中观察到的IGF-I受体可能与少突胶质细胞有关。
