Picillo Marina, Pivonello Rosario, Santangelo Gabriella, Pivonello Claudia, Savastano Riccardo, Auriemma Renata, Amboni Marianna, Scannapieco Sara, Pierro Angela, Colao Annamaria, Barone Paolo, Pellecchia Maria Teresa
Center for Neurodegenerative Diseases (CEMAND), Department of Medicine and Surgery, Neuroscience Section, University of Salerno, Salerno, Italy.
Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
PLoS One. 2017 Oct 24;12(10):e0186508. doi: 10.1371/journal.pone.0186508. eCollection 2017.
Cognitive deficits are common in Parkinson's disease (PD) since the early stages and many patients eventually develop dementia. Yet, occurrence of dementia in PD is unpredictable. Evidence supports the hypothesis that insulin-like growth factor-1 (IGF-1) is involved in cognitive deficits. Our aim was to evaluate the relationship between serum IGF-1 levels and neuropsychological scores in a large cohort of drug-naïve PD patients during the earliest stages of the disease.
Serum IGF-1 levels were determined in 405 early, drug-naïve PD patients and 191 healthy controls (HC) enrolled in the Parkinson's Progression Markers Initiative (PPMI). The association between serum IGF-1 levels and neuropsychological scores was evaluated with linear regression analysis.
IGF-1 levels were similar in PD and HC. In PD patients the lowest IGF-1 quartile was a predictor of lower performances at the Semantic Fluency task (β = -3.46, 95%CI: -5.87 to -1.01, p = 0.005), the Symbol Digit Modalities Score (β = -2.09, 95%CI: -4.02 to -0.15, p = 0.034), and Hopkins Verbal Learning Test Retention (β = -0.05, 95%CI: -0.09 to -0.009, p = 0.019).
Lower serum IGF-1 levels are associated to poor performances in cognitive tasks assessing executive function, attention and verbal memory in a large cohort of early PD patients. Follow-up studies are warranted to assess if IGF-1 is related to the development of dementia in PD.
认知缺陷在帕金森病（PD）早期很常见，许多患者最终会发展为痴呆。然而，PD患者中痴呆的发生是不可预测的。有证据支持胰岛素样生长因子-1（IGF-1）参与认知缺陷的假说。我们的目的是在一大群疾病早期未接受过药物治疗的PD患者中评估血清IGF-1水平与神经心理学评分之间的关系。
在帕金森病进展标志物计划（PPMI）中纳入的405例早期未接受过药物治疗的PD患者和191名健康对照（HC）中测定血清IGF-1水平。通过线性回归分析评估血清IGF-1水平与神经心理学评分之间的关联。
PD患者和HC的IGF-1水平相似。在PD患者中，最低的IGF-1四分位数是语义流畅性任务表现较低的预测因素（β = -3.46，95%CI：-5.87至-1.01，p = 0.005）、符号数字模式评分（β = -2.09，95%CI：-4.02至-0.15，p = 0.034）以及霍普金斯言语学习测试记忆保持率（β = -0.05，95%CI：-0.09至-0.009，p = 0.019）的预测因素。
在一大群早期PD患者中，较低的血清IGF-1水平与评估执行功能、注意力和言语记忆的认知任务表现不佳有关。有必要进行后续研究以评估IGF-1是否与PD患者痴呆的发展有关。
