Conrad S, Schneider A W, Gonnermann D, Ganama A, Tenschert W, Huland H
Urologische Universitätsklinik Hamburg-Eppendorf.
Urologe A. 1994 Sep;33(5):392-400.
A total of 539 renal transplantations were performed at the Department of Urology of the University Hospital of Hamburg between 1984 and 1991. 132 (24.5%) patients developed urological complications (by definition, complications occurring as a result of the operative procedure). In 31 cases the transplants had to be removed secondary to urological complications, and 4 patients died of such complications (mortality 0.7%, lethality 3.0%). Urinary tract infections occurred in 13.2% of all patients during the first postoperative year and were by far the most frequent complication, followed by haematomas, which occurred in 9.6%. The incidence of urinary tract and wound infections was significantly reduced during the 8-year period studied by improving antibiotic prophylaxis and adopting a strategy of early removal of indwelling catheters (P < 0.05). Stenting the ureteroneocystostomy with a double-J stent instead of an external ureteral catheter resulted in a definite decrease in the incidence of ureteral leaks (P < 0.05). Continuous control of operative results and efforts to improve operative and perioperative strategies make it possible to reduce the incidence of urological complications in renal transplantation and thus result in an improved graft function and patient survival.
1984年至1991年间,汉堡大学医院泌尿外科共进行了539例肾移植手术。132例(24.5%)患者出现了泌尿系统并发症(根据定义,指因手术操作导致的并发症)。31例患者因泌尿系统并发症不得不切除移植肾,4例患者死于此类并发症(死亡率0.7%,致死率3.0%)。术后第一年,13.2%的患者发生了尿路感染,这是迄今为止最常见的并发症,其次是血肿,发生率为9.6%。在研究的8年期间,通过改进抗生素预防措施和采取早期拔除留置导管的策略,尿路和伤口感染的发生率显著降低(P<0.05)。用双J支架而非外置输尿管导管对输尿管膀胱吻合口进行支架置入,可使输尿管漏的发生率明显降低(P<0.05)。持续监控手术效果并努力改进手术及围手术期策略,能够降低肾移植中泌尿系统并发症的发生率,从而改善移植肾功能和患者生存率。