Koretz J F, Cook C A, Kuszak J R
Center for Biophysics, Rensselaer Polytechnic Institute, Troy, NY 12180-3590.
Vision Res. 1994 Nov;34(22):2955-62. doi: 10.1016/0042-6989(94)90267-4.
Statistical analysis of Scheimpflug images from the crystalline lenses of 100 emmetropic human subjects ranging in age from 18 to 70 yr confirms that specific zones of discontinuity are a function of lens development and growth. At and beyond the age of 40 yr, as many as four sharply demarcated and complementary zones are seen within the anterior and posterior lens cortex. The locations of the inner edges of the anterior cortical zones of discontinuity were characterized relative to the central sulcus of the lens. Consecutively from the central sulcus, the distances were 1.094, 1.415, 1.695, and 1.994 (+/- 0.11 mm). Since nuclear thickness in the adult lens is age-independent and the rate of cortical growth has been characterized, the location of the inner margins of the zones are indicative of the age at which they originated; these ages were 4 (+/- 1 yr), 9 (+/- 2 yr), 19 (+/- 4yr), and 46 (+/- 10 yr). All of the zones become broader along the outer margin and more dense upon aging, with specific zones appearing to merge in older presbyopic lenses. While lens fetal nuclear transparency decreases with age, it does not feature zones of discontinuity; instead, symmetrically amorphous regions appear centrally in the anterior and posterior nucleus. This demonstration of the onset of specific zones of discontinuity in emmetropic individuals, at defined periods of lens growth that are synchronous the production of successively more complex lens sutures, strongly suggests a causal relationship between lens sutures and the zones of discontinuity.
对年龄在18至70岁之间的100名正视眼人类受试者的晶状体进行的Scheimpflug图像统计分析证实，特定的不连续区域是晶状体发育和生长的函数。在40岁及以上，在前、后晶状体皮质内可看到多达四个界限清晰且互补的区域。相对于晶状体中央沟，对前皮质不连续区域内边缘的位置进行了表征。从中央沟开始，连续距离分别为1.094、1.415、1.695和1.994（±0.11毫米）。由于成人晶状体核厚度与年龄无关，且已对皮质生长速率进行了表征，因此这些区域内边缘的位置表明了它们形成时的年龄；这些年龄分别为4（±1岁）、9（±2岁）、19（±4岁）和46（±10岁）。所有区域沿外缘变宽，且随着年龄增长密度增加，在老年老花眼中特定区域似乎会合并。虽然晶状体胎儿核透明度随年龄降低，但它没有不连续区域；相反，在前、后核中央对称地出现无定形区域。在正视眼个体中，在与依次产生更复杂晶状体缝线同步的晶状体生长特定时期，特定不连续区域开始出现，这有力地表明晶状体缝线与不连续区域之间存在因果关系。
