Hrycek A, Dabek J, Zielińska-Stasiura H, Kłaptocz B, Nowakowska M, Radosz-Komoniewska H
II Katedry i Kliniki Chorób Wewnetrznych Sl. Ak. Med.
Wiad Lek. 1994 Feb;47(3-4):84-7.
In 20 patients with active, endoscopically confirmed duodenal ulcer, serum lysozyme activity, metabolic and phagocytic activity of neutrophils using the NBT spontaneous and stimulated test and stimulated test, and cytoenzymatic reaction for alkaline phosphatase were evaluated before treatment and after two weeks of treatment with ranitidine 150 mg every 12 hours. In some of the studies carried out the differences were obtained between the mean results which turned out to be statistically significant. In the group of patients with duodenal ulcer after two weeks of treatment with ranitidine, a statistically significant increase was found of diluted serum lysozyme activity as compared to the activity of this enzyme before the treatment. After the treatment with ranitidine, a statistically highly significant increase was noted of alkaline phosphatase activity in the neutrophils as compared to the activity of this enzyme assessed in patients with untreated duodenal ulcer. On the basis of the obtained results of studies the conclusions were formulated: 1) The increase of diluted serum lysozyme activity in the patients with duodenal ulcer after two weeks of treatment with ranitidine may evidence the presence of inhibitors of the enzyme in the serum of the studied group. 2) In patients with duodenal ulcer after two weeks of treatment with ranitidine the activity increases of cytoenzymatically determined alkaline phosphatase in the neutrophils, while the cytoenzymatically determined values of the markers in the test with NBT remain unchanged.
在20例经内镜确诊为活动性十二指肠溃疡的患者中，在治疗前以及使用雷尼替丁（每12小时150毫克）治疗两周后，评估血清溶菌酶活性、中性粒细胞利用NBT自发和刺激试验的代谢及吞噬活性以及碱性磷酸酶的细胞酶反应。在一些所开展的研究中，平均结果之间存在差异，结果证明具有统计学意义。在十二指肠溃疡患者组中，使用雷尼替丁治疗两周后，与治疗前该酶的活性相比，发现稀释血清溶菌酶活性有统计学意义的增加。使用雷尼替丁治疗后，与未经治疗的十二指肠溃疡患者中评估的该酶活性相比，中性粒细胞中碱性磷酸酶活性有统计学高度显著的增加。根据所获得的研究结果得出以下结论：1）十二指肠溃疡患者使用雷尼替丁治疗两周后，稀释血清溶菌酶活性增加，这可能证明研究组血清中存在该酶的抑制剂。2）十二指肠溃疡患者使用雷尼替丁治疗两周后，中性粒细胞中细胞酶测定的碱性磷酸酶活性增加，而在NBT试验中细胞酶测定的标志物值保持不变。
