Piotrowski J, Piotrowska E
Katedry i Kliniki Chorób Wewnetrznych i Zawodowych, Zabrzu.
Pol Tyg Lek. 1993;48(11-13):271-3.
Functioning of hepatocytes has been assessed with respiratory test with aminopyrine labelled with 14C radioisotope in patients with duodenal ulcer treated with ranitidine. Reversibility of changes in liver microsomal system at different intervals after the completion of therapy has also been evaluated. Altogether 30 patients with duodenal ulcer treated with ranitidine have been examined: prior to the treatment--group Ia, after one day of ranitidine administration--group Ib, within 4 weeks of therapy--group Ic, within 8 weeks of therapy--group Id, and one week after the completion of the treatment--group Ie, as well as after a 4-week follow-up period--group If. Significant decrease in the results of respiratory test has been noted in patients treated with ranitidine after both four and eight weeks. Activity of liver mono-oxidases approached baseline values after one week following the completion of therapy. The results of routine liver functioning tests in all patients of groups I and II have been within normal values. The obtained results suggest that patients treated with ranitidine should cautiously be given other medicines, especially those affecting liver functioning or metabolized in the liver.
在使用雷尼替丁治疗的十二指肠溃疡患者中，已通过用14C放射性同位素标记的氨基比林进行呼吸试验来评估肝细胞的功能。还评估了治疗结束后不同时间间隔肝脏微粒体系统变化的可逆性。总共检查了30例用雷尼替丁治疗的十二指肠溃疡患者：治疗前——Ia组，服用雷尼替丁一天后——Ib组，治疗4周内——Ic组，治疗8周内——Id组，治疗结束后一周——Ie组，以及4周随访期后——If组。在治疗4周和8周后，使用雷尼替丁治疗的患者呼吸试验结果显著下降。治疗结束一周后，肝脏单氧化酶的活性接近基线值。I组和II组所有患者的常规肝功能检查结果均在正常范围内。所得结果表明，接受雷尼替丁治疗的患者应谨慎使用其他药物，尤其是那些影响肝功能或在肝脏中代谢的药物。
