Goodfield M J, Hull S M, Cunliffe W J
Department of Dermatology, General Infirmary, Leeds, U.K.
Acta Derm Venereol. 1994 Jul;74(4):295-7. doi: 10.2340/0001555574295297.
We have investigated the systemic effect of local treatment with dithranol for one week in psoriasis by a combination of subjective assessment of the severity of individual plaques and more objective assessment of blood flow (measured by laser-Doppler flowmetry) of the centre of the plaque, and at the active edge of the plaque. There is both subjective and objective evidence of an improvement in untreated plaques of psoriasis when dithranol is used on plaques elsewhere on the body. Blood flow falls at the active edge and at the centre of the plaques that are untreated. These findings indicate a systemic effect of local treatment that is more likely to be due to circulating factors, possibly T cells, rather than a direct effect of circulating dithranol. They also suggest that within patient comparisons of topical treatment in psoriasis may be inaccurate.
我们通过结合对单个斑块严重程度的主观评估以及对斑块中心和斑块活跃边缘血流（用激光多普勒血流仪测量）更客观的评估，研究了用蒽林局部治疗一周对银屑病的全身影响。当在身体其他部位的斑块上使用蒽林时，有主观和客观证据表明未治疗的银屑病斑块有所改善。未治疗的斑块的活跃边缘和中心的血流会下降。这些发现表明局部治疗具有全身效应，这种效应更可能是由于循环因子，可能是T细胞，而不是循环蒽林的直接作用。它们还表明，在患者体内比较银屑病局部治疗效果可能不准确。
