Rogers S
City of Dublin Skin and Cancer Hospital, Ireland.
Clin Exp Dermatol. 1993 Jan;18(1):21-4. doi: 10.1111/j.1365-2230.1993.tb00959.x.
Pre-treatment plaque thickness determined the rate at which psoriasis responded to PUVA treatment, taking longer with thicker plaques. For dithranol, the rate of response to treatment was independent of pre-treatment plaque thickness. Plaques of psoriasis that showed the greatest evaporative water loss before treatment took longest to clear with PUVA. At the time of clinical clearing the water loss had returned to that of adjacent, uninvolved skin. With dithranol the evaporative water loss did not return to normal levels but remained considerably elevated when the plaque was clinically clear.
治疗前的斑块厚度决定了银屑病对补骨脂素紫外线A（PUVA）治疗的反应速度，斑块越厚，所需时间越长。对于地蒽酚，治疗反应速度与治疗前的斑块厚度无关。治疗前蒸发失水最多的银屑病斑块，用PUVA清除所需时间最长。临床清除时，失水量已恢复至相邻未受累皮肤的水平。使用地蒽酚时，蒸发失水并未恢复至正常水平，而是在斑块临床清除时仍显著升高。
