Berth-Jones J, Mc Burney A, Hutchinson P E
Department of Dermatology, Leicester Royal Infirmary, UK.
Acta Derm Venereol. 1994 Jul;74(4):312-3. doi: 10.2340/0001555574312313.
Diphencyprone is a potent contact sensitizer in widespread use for treatment of alopecia areata. It is currently not known whether this compound is absorbed following topical application. This is important, since little is known regarding potential toxicity. We therefore analysed serum and urine samples following application of at least 0.5 ml of a 1% solution of diphencyprone to the scalp of patients under treatment for alopecia areata. Serum samples were obtained over 8 h following treatment and 24-h urine collections were performed. The threshold for detection was 2 ng, and the assay gave an accurate linear response for samples of serum and urine containing known concentrations of diphencyprone. Blood and/or urine samples were obtained from a total of 18 subjects. Diphencyprone was not detected in any sample of serum or urine from the subjects. These data suggest that diphencyprone is not absorbed following application to the skin.
二苯环丙烯酮是一种广泛用于治疗斑秃的强效接触性致敏剂。目前尚不清楚该化合物经局部应用后是否会被吸收。这一点很重要，因为人们对其潜在毒性知之甚少。因此，我们对接受斑秃治疗的患者头皮应用至少0.5毫升1%二苯环丙烯酮溶液后采集的血清和尿液样本进行了分析。治疗后8小时内采集血清样本，并进行24小时尿液收集。检测阈值为2纳克，该检测方法对含有已知浓度二苯环丙烯酮的血清和尿液样本给出了准确的线性响应。总共从18名受试者中采集了血液和/或尿液样本。在受试者的任何血清或尿液样本中均未检测到二苯环丙烯酮。这些数据表明，二苯环丙烯酮经皮肤应用后不会被吸收。
