Pfau A, Hohenleutner U, Hohenleutner S, Eckert F, Landthaler M
Department of Dermatology, University of Regensberg, Germany.
Acta Derm Venereol. 1994 Jul;74(4):314-6. doi: 10.2340/0001555574314316.
A 71-year-old woman had noticed the development of blisters on her forehead 4 months before she was referred to our department. Treatment with oral corticosteroids resulted in complete healing, but new blisters subsequently developed on the face, neck and backs of the hands. After the possibility of phototoxic and photoallergic reactions, as well as an abnormal porphyrin profile, had been excluded, the diagnosis of bullous pemphigoid was made by histological and direct immunofluorescent examination. UV-A provocation on the upper arm produced lesions histologically and immunohistochemically typical of bullous pemphigoid. Of particular importance was the fact that the blisters were limited strictly to light-exposed skin areas.
一名71岁女性在被转诊至我科前4个月注意到前额出现水疱。口服糖皮质激素治疗后水疱完全愈合，但随后面部、颈部和手背又出现了新的水疱。在排除了光毒性和光过敏反应以及卟啉谱异常的可能性后，通过组织学和直接免疫荧光检查确诊为大疱性类天疱疮。上臂进行紫外线A激发试验产生了组织学和免疫组织化学上典型的大疱性类天疱疮病变。特别重要的是，水疱严格局限于暴露于光的皮肤区域。
