Velikay M, Binder S, Stolba U, Wedrich A, Datlinger P, Handl-Zeller L
1st University Eye Clinic, Vienna, Austria.
Acta Ophthalmol (Copenh). 1994 Jun;72(3):337-40. doi: 10.1111/j.1755-3768.1994.tb02769.x.
Since 1980, the fibroblast model creating experimental proliferative vitreoretinopathy has been used to evaluate the antiproliferative effect of various drugs. In previous studies radiation therapy was found to reduce effectively intraocular proliferation in this model. We therefore investigated the effect of high energy electrons in a standard perforating injury model creating a traumatic proliferative vitreoretinopathy. In 36 eyes we performed a 8 mm pars plana incision and injected 0.4 ml of 80% fibronectin solution intravitreally. Ten rabbits (20 eyes) received radiation therapy with a Betatron accelerator in a total dosage of 3000 cGy to each eye divided into 10 single fractions starting on the first post-operative day. Maximum concentration of the dose was focused to the posterior vitreous. The other 9 rabbits, 18 eyes, served as control. In our perforating injury model we observed a reduction of retinal detachment rate of 72% in the controls to 55% in the treated group. The effect of radiation therapy with high energy electrons and total dosage of 3000 cGy was not statistically significant in experimental traumatic proliferative vitreoretinopathy.
自1980年以来，用于创建实验性增殖性玻璃体视网膜病变的成纤维细胞模型已被用于评估各种药物的抗增殖作用。在先前的研究中，发现放射治疗可有效降低该模型中的眼内增殖。因此，我们在一个创建外伤性增殖性玻璃体视网膜病变的标准穿孔伤模型中研究了高能电子的作用。在36只眼中，我们进行了8毫米的扁平部切口，并向玻璃体内注射了0.4毫升80%的纤连蛋白溶液。10只兔子（20只眼）从术后第一天开始，使用电子感应加速器进行放射治疗，每只眼的总剂量为3000厘戈瑞，分为10个单次剂量，最大剂量集中在玻璃体后部。另外9只兔子（18只眼）作为对照。在我们的穿孔伤模型中，我们观察到对照组的视网膜脱离率从72%降至治疗组的55%。在实验性外伤性增殖性玻璃体视网膜病变中，3000厘戈瑞总剂量的高能电子放射治疗效果无统计学意义。
