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外照射放疗后双侧孔源性视网膜脱离:只是巧合吗?

Bilateral rhegmatogenous retinal detachment after external-beam radiotherapy: just a coincidence?

作者信息

Kodjikian Laurent, Garweg Justus G, Fleury Jacques, Rocher François, Burillon Carole, Grange Jean-Daniel

机构信息

Department of Ophthalmology, Croix-Rousse Hospital, 103, grande rue de la Croix-Rousse, 69004 Lyon, France.

出版信息

Graefes Arch Clin Exp Ophthalmol. 2004 Jun;242(6):523-6. doi: 10.1007/s00417-004-0860-8. Epub 2004 Mar 24.

DOI:10.1007/s00417-004-0860-8
PMID:15042376
Abstract

PURPOSE

To report an unusual case of almost simultaneous bilateral rhegmatogenous retinal detachment in the context of external-beam radiotherapy for a tumor at a non-ocular target site and in the absence of pre-existing ocular pathology.

METHODS

Observational case report with review of corresponding literature.

RESULTS

A 63-year-old man was referred for bilateral retinal detachment which was associated with many horseshoe tears and proliferative vitreoretinopathy. He had undergone surgery for a carcinoma of the left maxillary sinus 4 months prior to the presentation and had then received external-beam radiotherapy for 3 months. There was no familial history of retinal detachment and/or eye trauma in this hyperopic patient with clear native lenses. No chorioretinal pathology was apparent that could have predisposed the retinas to tearing.

CONCLUSIONS

Simultaneous bilateral retinal detachment is exceptional, especially in a patient with no risk factors. The effect of radiotherapy on the vitreoretinal interface is discussed in the light of existing data and may have been responsible for our patient's retinal detachment.

摘要

目的

报告一例罕见病例,患者在非眼部靶部位肿瘤的外照射放疗过程中,在无眼部既往病变的情况下,几乎同时发生双侧孔源性视网膜脱离。

方法

观察性病例报告并回顾相关文献。

结果

一名63岁男性因双侧视网膜脱离前来就诊,伴有多处马蹄形裂孔和增生性玻璃体视网膜病变。他在就诊前4个月接受了左上颌窦癌手术,随后接受了3个月的外照射放疗。该远视患者晶状体清晰,无视网膜脱离和/或眼外伤家族史。未发现明显的脉络膜视网膜病变可能使视网膜易于撕裂。

结论

双侧同时性视网膜脱离很罕见,尤其是在无危险因素的患者中。根据现有数据讨论了放疗对玻璃体视网膜界面的影响,这可能是导致我们这位患者视网膜脱离的原因。

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Combined plaque radiotherapy and transpupillary thermotherapy for choroidal melanoma: tumor control and treatment complications in 270 consecutive patients.脉络膜黑色素瘤的联合斑块放射治疗和经瞳孔温热疗法:270例连续患者的肿瘤控制和治疗并发症
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Rhegmatogenous retinal detachment in eyes with uveal melanoma.葡萄膜黑色素瘤患者的孔源性视网膜脱离
Retina. 1996;16(6):488-96. doi: 10.1097/00006982-199616060-00004.
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Posterior ocular abnormalities after irradiation for retinoblastoma: a histopathological study.视网膜母细胞瘤放疗后眼部后部异常:一项组织病理学研究
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Simulation of massive periretinal proliferation by autotransplantation of retinal pigment epithelial cells in rabbits.
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