Marmarou A
Division of Neurosurgery, Medical College of Virginia, Richmond.
Acta Neurochir Suppl (Wien). 1994;60:421-4. doi: 10.1007/978-3-7091-9334-1_114.
This article provides a brief summary of concepts describing the formation and resolution of traumatic brain edema. Recent laboratory and clinical data are reviewed targeted toward resolving the contribution of edema to the swelling process. These data, indicate that blood volume is reduced in areas of ischemia following traumatic injury and edema volume is increased. Thus, edema is the major contributor to the swelling process in diffuse injury. As clinical MRI studies have not revealed barrier compromise in the presence of swelling, it is considered that other forms of edema, primarily ischemic and neurotoxic, make a substantial contribution to the edema volume.
本文简要概述了描述创伤性脑水肿形成和消退的概念。回顾了近期的实验室和临床数据，旨在阐明水肿在肿胀过程中的作用。这些数据表明，创伤性损伤后缺血区域的血容量减少，而水肿体积增加。因此，水肿是弥漫性损伤肿胀过程的主要促成因素。由于临床MRI研究未发现肿胀时存在屏障破坏，因此认为其他形式的水肿，主要是缺血性和神经毒性水肿，对水肿体积有很大影响。
