Młynarska M S
Institute of Pharmacology, Polish Academy of Sciences, Krakow.
Agents Actions. 1994 Jun;41 Spec No:C82-4. doi: 10.1007/BF02007777.
Histamine (HA) was given intracerebroventricularly (icv) to rats anaesthetized with pentobarbital. During the first minute after administration, HA alone elicited a small fall in blood pressure (BP) and a decrease in heart rate (HR), followed by a distinct increase in those parameters. Pretreatment with naloxone (Nx) in a dose of 0.1 microgram icv significantly decreased the rise in BP and augmented the increase in HR. When the rats were premedicated with atropine methyl bromide (ATMB), 15 min before histamine, higher doses of ATMB (100 micrograms icv or 25 micrograms ip) significantly inhibited the histamine induced BP rise. However, a very small dose (0.1 microgram) of ATMB stimulated the hypertensive response, but only after its peripheral and not central application. These changes were significantly reversed by icv pretreatment with Nx. HA-induced changes in HR, in contrast to BP, were not significantly modified by ATMB.
将组胺（HA）经脑室注射（icv）给予用戊巴比妥麻醉的大鼠。给药后的第一分钟内，单独给予HA会引起血压（BP）小幅下降和心率（HR）降低，随后这些参数会明显升高。以0.1微克icv的剂量用纳洛酮（Nx）预处理可显著降低BP的升高并增强HR的增加。当在给予组胺前15分钟用甲基溴化阿托品（ATMB）对大鼠进行预处理时，较高剂量的ATMB（100微克icv或25微克腹腔注射）可显著抑制组胺诱导的BP升高。然而，非常小剂量（0.1微克）的ATMB会刺激高血压反应，但仅在其外周而非中枢给药后才会出现。通过icv用Nx预处理可显著逆转这些变化。与BP相反，HA诱导的HR变化未被ATMB显著改变。
