组胺诱导的、中枢神经系统介导的高血糖症在大脑中被阿托品抑制。

Histamine-induced, central nervous system-mediated hyperglycemia is suppressed by atropine in the brain.

作者信息

Nonogaki K, Li X, Tamagawa T, Watanabe G, Hiyoshi Y, Ozawa K, Sakamoto N, Iguchi A

机构信息

Third Department of Internal Medicine, Nagoya University School of Medicine, Japan.

出版信息

Life Sci. 1993;52(15):PL107-10. doi: 10.1016/0024-3205(93)90096-l.

DOI:10.1016/0024-3205(93)90096-l

PMID:8096617

Abstract

We investigated the relationship between histamine and muscarinic cholinergic neurons in central nervous system (CNS)-mediated glucose regulation in anesthetized fed rats. The injection of pyrilamine (5 x 10(-7) mol) into the third cerebral ventricle suppressed the hyperglycemia induced by intraventricular injection of histamine (5 x 10(-7) mol). Ranitidine (5 x 10(-7) mol), however, did not suppress this hyperglycemia. The injection of atropine (5 x 10(-9)-5 x 10(-7) mol) into the third cerebral ventricle suppressed the histamine-induced hyperglycemia in a dose-dependent manner. These findings suggest that histamine induction of CNS-mediated hyperglycemia involves neuronal transmission not only via H1 receptors but also, at least in part, by muscarinic cholinergic neurons.

摘要

我们研究了组胺与中枢神经系统（CNS）介导的麻醉状态下进食大鼠血糖调节中的毒蕈碱型胆碱能神经元之间的关系。向第三脑室注射吡苄明（5×10⁻⁷摩尔）可抑制脑室内注射组胺（5×10⁻⁷摩尔）诱导的高血糖。然而，雷尼替丁（5×10⁻⁷摩尔）并未抑制这种高血糖。向第三脑室注射阿托品（5×10⁻⁹ - 5×10⁻⁷摩尔）以剂量依赖方式抑制组胺诱导的高血糖。这些发现表明，CNS介导的高血糖的组胺诱导不仅涉及通过H1受体的神经元传递，而且至少部分地通过毒蕈碱型胆碱能神经元。