Rosenfeld J A
East Tennessee State University, Bristol.
Am Fam Physician. 1994 Nov 15;50(7):1519-23, 1527-8.
Estrogen replacement therapy is recommended for the prevention of osteoporosis and the attenuation of symptoms associated with menopause. Compliance may be a problem with sequential regimens of estrogen and progestin. To address this issue, continuous-dosing regimens of estrogen and progestin have been used. These regimens cause significantly less cyclic and intermenstrual bleeding and induce amenorrhea in most women, which should enhance compliance.
推荐使用雌激素替代疗法来预防骨质疏松症并减轻与更年期相关的症状。雌激素和孕激素的序贯疗法可能存在依从性问题。为解决这一问题，已采用雌激素和孕激素的连续给药方案。这些方案导致的周期性和经间期出血明显减少，并且在大多数女性中会诱导闭经，这应该会提高依从性。
