Dolan-Mullen P, Ramírez G, Groff J Y
Center for Health Promotion Research and Development, University of Texas School of Public Health, Houston 77225.
Am J Obstet Gynecol. 1994 Nov;171(5):1328-34. doi: 10.1016/0002-9378(94)90156-2.
Our purpose was to assess the effect of prenatal smoking interventions on rates of smoking cessation and low birth weight.
We used a meta-analysis model to compare and summarize smoking cessation and low birth weight outcomes with the risk ratio used as a common metric. We located 11 randomized, controlled trials with objective validation of smoking status; four of these studies also measured rates of low birth weight.
Risk ratios for smoking cessation ranged from 0.9 to 7.1. The combined risk ratio for the homogeneous group of 10 studies was 1.50 (95% confidence interval 1.22 to 1.86) after the outlier study with a risk ratio of 7.1 was excluded. This was a 50% increase in smoking cessation. Low birth weight risk ratios of 0.6 for two studies that achieved a 50% increase in cessation suggested that the incidence of low birth weight was decreased.
Prenatal smoking cessation interventions increase rates of smoking cessation during pregnancy, and there is evidence that they reduce the incidence of low birth weight.
我们的目的是评估产前吸烟干预对戒烟率和低出生体重发生率的影响。
我们使用荟萃分析模型，以风险比作为共同指标来比较和总结戒烟及低出生体重的结果。我们找到了11项对吸烟状况进行客观验证的随机对照试验；其中四项研究还测量了低出生体重发生率。
戒烟的风险比在0.9至7.1之间。在排除风险比为7.1的异常研究后，10项同类研究的合并风险比为1.50（95%置信区间1.22至1.86）。这表明戒烟率提高了50%。两项戒烟率提高了50%的研究中，低出生体重风险比为0.6，这表明低出生体重的发生率有所降低。
产前戒烟干预可提高孕期戒烟率，且有证据表明这些干预可降低低出生体重的发生率。
