Ota K, Namiki A, Iwasaki H, Takahashi I
Department of Anesthesiology, Sapporo Medical College and Hospital, Hokkaido, Japan.
Anesth Analg. 1994 Dec;79(6):1117-20.
This study was designed to evaluate the optimal administration time of oral clonidine as premedication for the prolongation of tetracaine spinal anesthesia in humans. Forty male patients scheduled for urologic surgery were studied. Patients were allocated randomly into four groups given 15 mg of 0.5% isobaric tetracaine. Group 1 was given 250 micrograms triazolam orally 1 h before anesthesia. Groups 2, 3, and 4 were administered 150 micrograms oral clonidine just before anesthesia or 1 h and 3 h before anesthesia respectively. Sensory block was assessed by pinprick. Groups 2 and 3 had a significantly prolonged time of sensory block (74%-94%, P < 0.01) when compared with Group 1. However, the prolonging effect of oral clonidine was not apparent in Group 4. We conclude that, when administered within 1 h before anesthesia, oral clonidine, at a dose of 150 micrograms, produced a significant prolongation of tetracaine spinal anesthesia without adverse effects.
本研究旨在评估口服可乐定作为术前用药对丁卡因腰麻在人体中作用时间延长的最佳给药时间。对40例计划行泌尿外科手术的男性患者进行了研究。患者被随机分为四组，均给予15mg的0.5%等比重丁卡因。第1组在麻醉前1小时口服250μg三唑仑。第2、3和4组分别在麻醉前、麻醉前1小时和麻醉前3小时口服150μg可乐定。通过针刺评估感觉阻滞。与第1组相比，第2组和第3组的感觉阻滞时间显著延长（74%-94%，P<0.01）。然而，第4组中口服可乐定的延长作用并不明显。我们得出结论，在麻醉前1小时内给予150μg剂量的口服可乐定可显著延长丁卡因腰麻的作用时间且无不良反应。
