Ota K, Namiki A, Iwasaki H, Takahashi I
Department of Anesthesiology, Sapporo Medical College and Hospital, Hokkaido, Japan.
Anesth Analg. 1994 Dec;79(6):1121-5.
The prolonging effects of oral clonidine on sensory block during tetracaine spinal anesthesia were studied in 47 healthy patients scheduled for urologic or gynecologic surgery. All patients received 15 mg tetracaine intrathecally in isobaric saline. The patients were randomly allocated into four groups. Group 1 (n = 13) was administered 0.25 mg triazolam orally. Group 2 (n = 12), Group 3 (n = 12), and Group 4 (n = 10) received 75 micrograms, 150 micrograms, and 300 micrograms of oral clonidine, respectively. These drugs were administered 1 h before anesthesia. Sensory block was evaluated by pinprick. All regression times in Groups 2, 3, and 4 were significantly longer than those in Group 1. The prolonging effect of oral clonidine increased in a dose-dependent manner and reached a maximal effect at 150 micrograms. Four patients in Group 4 developed bradycardia (heart rate < 45 bpm), suggesting that the dose of 300 micrograms of oral clonidine may promote bradycardia during spinal anesthesia.
在47例计划接受泌尿外科或妇科手术的健康患者中，研究了口服可乐定对丁卡因脊髓麻醉期间感觉阻滞的延长作用。所有患者均在等比重盐水中鞘内注射15mg丁卡因。患者被随机分为四组。第一组（n = 13）口服0.25mg三唑仑。第二组（n = 12）、第三组（n = 12）和第四组（n = 10）分别口服75微克、150微克和300微克可乐定。这些药物在麻醉前1小时给药。通过针刺评估感觉阻滞。第二组、第三组和第四组的所有消退时间均显著长于第一组。口服可乐定的延长作用呈剂量依赖性增加，在150微克时达到最大效应。第四组有4例患者出现心动过缓（心率<45次/分），提示口服300微克可乐定可能会在脊髓麻醉期间促进心动过缓。
