Aplin J D, Seif M W, Graham R A, Hey N A, Behzad F, Campbell S
Department of Obstetrics and Gynaecology, University of Manchester, U.K.
Ann N Y Acad Sci. 1994 Sep 30;734:103-21. doi: 10.1111/j.1749-6632.1994.tb21739.x.
The cell surface mucin MUC-1 is present in endometrial epithelial cells and their associated apical glycocalyx and is also released into gland lumens as a secretory product. MUC-1 mRNA and core protein are found at low levels in the proliferative phase of the cycle, but their abundance increases after ovulation. Endometrial MUC-1 has been found to carry sialokeratan sulphate chains and these show a dramatically increased abundance in cells and secretions in the post-ovulatory phase of the cycle, reaching a maximum in secretions 6-7 days after the LH peak. The apical epithelium also contains adhesion receptor molecules of the integrin and CD44 families. MUC-1 is large and highly glycosylated and probably extends farther from the cell surface than these 'conventional' glycoprotein receptors. It has the potential to inhibit sterically receptor-mediated cell-cell adhesion. However, it is also possible that MUC-1 displays specific (e.g., glycan) recognition structures for the initial attachment of the blastocyst or that the embryo may create a specialised microenvironment in which to implant.
细胞表面黏蛋白MUC-1存在于子宫内膜上皮细胞及其相关的顶端糖萼中，并且作为分泌产物释放到腺腔中。在月经周期的增殖期，MUC-1信使核糖核酸（mRNA）和核心蛋白水平较低，但排卵后其丰度增加。已发现子宫内膜MUC-1带有硫酸唾液角蛋白链，并且这些链在月经周期的排卵后期细胞和分泌物中的丰度显著增加，在促黄体生成素（LH）峰后6-7天的分泌物中达到最大值。顶端上皮还含有整合素和CD44家族的黏附受体分子。MUC-1体积大且高度糖基化，可能比这些“传统”糖蛋白受体更远离细胞表面延伸。它有可能在空间上抑制受体介导的细胞间黏附。然而，MUC-1也可能展示用于胚泡初始附着的特异性（例如聚糖）识别结构，或者胚胎可能创造一个专门的微环境用于着床。
