Erny P, Chatelan M, Bourdalle-Badie C, Pontois M, Chevais R, Neverre G
Ann Anesthesiol Fr. 1975 Nov;16(7):501-12.
In order to study the hematologic repercussions of pre-operative autotransfusion, ruptures were made in experimental spleens followed by retransfusion after intraperitoneal barbotage of long duration in 8 dogs. This was performed without any heparinization. The following facts could be established:--although the blood shed was rich in red globules, it presented major alterations with a loss of clotting agents and evidence of fibrinogenic degradating elements.--A study of the blood during the transfusion and after the intervention did not reveal any intravascular coagulation but only a loss of fibrinogen and thrombocytes proportional to the amount of autotransfused blood. The limit of haemostatic tolerance with no supply of external blood was an autotransfusion ranging about 75 p. 100 of the initial blood volume.
为了研究术前自体输血的血液学影响,在8只狗的实验性脾脏上造成破裂,然后在长时间腹腔灌洗后进行回输。该操作未进行任何肝素化处理。可以确定以下事实:——尽管流出的血液富含红细胞,但它出现了主要变化,凝血因子丢失且有纤维蛋白原降解成分的迹象。——对输血期间和干预后的血液研究未发现任何血管内凝血,仅发现纤维蛋白原和血小板的丢失与自体输血量成比例。在不补充外源血液的情况下,止血耐受极限是自体输血约占初始血容量的75%。