接受二乙基二硫代氨基甲酸盐治疗的人类免疫缺陷病毒感染儿童和青年中血液中性粒细胞、单核细胞和血小板计数减少。
Decreased counts of blood neutrophils, monocytes, and platelets in human immunodeficiency virus-infected children and young adults treated with diethyldithiocarbamate.
作者信息
Shenep J L, Hughes W T, Flynn P M, Roberson P K, Behm F G, Fullen G H, Kovnar S G, Guito K P, Brodkey T O
机构信息
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
出版信息
Antimicrob Agents Chemother. 1994 Jul;38(7):1644-6. doi: 10.1128/AAC.38.7.1644.
Abstract
Nineteen young human immunodeficiency virus-infected patients were randomized to receive 400 mg of oral diethyldithiocarbamate (DTC) per m2 or placebo weekly for 12 weeks. Changes in blood CD4+ lymphocytes were not significantly different between groups. However, neutrophil, monocyte, and platelet counts consistently decreased during DTC treatment, suggesting DTC-mediated myelosuppression.
摘要
19名年轻的人类免疫缺陷病毒感染患者被随机分组，分别接受每平方米400毫克口服二乙二硫代氨基甲酸盐（DTC）或安慰剂治疗，每周一次，共12周。两组之间血液CD4 +淋巴细胞的变化无显著差异。然而，在DTC治疗期间，中性粒细胞、单核细胞和血小板计数持续下降，提示DTC介导的骨髓抑制。
相似文献
1
Decreased counts of blood neutrophils, monocytes, and platelets in human immunodeficiency virus-infected children and young adults treated with diethyldithiocarbamate.接受二乙基二硫代氨基甲酸盐治疗的人类免疫缺陷病毒感染儿童和青年中血液中性粒细胞、单核细胞和血小板计数减少。
Antimicrob Agents Chemother. 1994 Jul;38(7):1644-6. doi: 10.1128/AAC.38.7.1644.
2
3
4
Multicenter, randomized, placebo-controlled study of ditiocarb (Imuthiol) in human immunodeficiency virus-infected asymptomatic and minimally symptomatic patients. The HIV87 Study Group.二硫卡钠（依木硫醇）在人类免疫缺陷病毒感染的无症状和症状轻微患者中的多中心、随机、安慰剂对照研究。HIV87研究组。
AIDS Res Hum Retroviruses. 1993 Jan;9(1):83-9. doi: 10.1089/aid.1993.9.83.
5
Low blood CD8+ T-lymphocytes and high circulating monocytes are predictors of HIV-1-associated progressive encephalopathy in children.血液中CD8 + T淋巴细胞水平低和循环单核细胞水平高是儿童HIV-1相关进行性脑病的预测指标。
Pediatrics. 2003 Feb;111(2):E168-75. doi: 10.1542/peds.111.2.e168.
6
Decreased plasma membrane fluidity of peripheral blood lymphocytes after diethyldithiocarbamate (DTC) therapy in HIV-infected patients.
Eur J Clin Pharmacol. 1989;37(5):521-3. doi: 10.1007/BF00558135.
7
A randomized, controlled dose response study of intravenous sodium diethyldithiocarbamate in patients with advanced human immunodeficiency virus infection.一项针对晚期人类免疫缺陷病毒感染患者的静脉注射二乙基二硫代氨基甲酸钠的随机对照剂量反应研究。
Life Sci. 1989;45(22):iii-ix. doi: 10.1016/0024-3205(89)90070-2.
8
Differential effects of testosterone on circulating neutrophils, monocytes, and platelets in men: Findings from two trials.睾酮对男性循环中性粒细胞、单核细胞和血小板的影响差异：两项试验的结果。
Andrology. 2020 Sep;8(5):1324-1331. doi: 10.1111/andr.12834. Epub 2020 Jul 2.
9
Randomised, double-blind, placebo-controlled trial of ditiocarb sodium ('Imuthiol') in human immunodeficiency virus infection.二硫卡钠（“免疫硫醇”）治疗人类免疫缺陷病毒感染的随机、双盲、安慰剂对照试验。
Lancet. 1988 Sep 24;2(8613):702-6. doi: 10.1016/s0140-6736(88)90184-5.
10
Diethyldithiocarbamate (ditiocarb sodium) effect on arachidonic acid metabolism in human mononuclear cells. Glutathione peroxidase-like activity.二乙基二硫代氨基甲酸盐（二硫卡钠）对人单核细胞中花生四烯酸代谢的影响。谷胱甘肽过氧化物酶样活性。
Biochem Pharmacol. 1992 Mar 17;43(6):1319-29. doi: 10.1016/0006-2952(92)90509-h.
引用本文的文献
1
Dithiocarbamates and viral IL-10 collaborate in the immortalization and evasion of immune response in EBV-infected human B lymphocytes.二硫代氨基甲酸盐与病毒白细胞介素-10协同作用，使EB病毒感染的人类B淋巴细胞永生化并逃避免疫反应。
Chem Biol Interact. 2008 Mar 10;172(1):81-92. doi: 10.1016/j.cbi.2007.11.005. Epub 2007 Nov 22.
本文引用的文献
1
[Protection against acute copper poisoning using chelating substances].
Boll Soc Ital Biol Sper. 1955 Jul-Aug;31(7-8):867-70.
2
The influence of diethyl-dithiocarbamate ('Imuthiol') on mononuclear cells in vitro.二乙基二硫代氨基甲酸盐（“免疫硫醇”）对体外单核细胞的影响。
Int J Immunopharmacol. 1984;6(3):245-7. doi: 10.1016/0192-0561(84)90023-7.
3
The effects of the protracted administration of the chelating agent, sodium diethyldithiocarbamate (dithiocarb).螯合剂二乙基二硫代氨基甲酸钠（二硫代氨基甲酸盐）长期给药的效果。
Am J Med Sci. 1967 Jul;254(1):24-34. doi: 10.1097/00000441-196707000-00003.
4
Clinical characterization of imuthiol.免疫硫醇的临床特征
Methods Find Exp Clin Pharmacol. 1986 Jan;8(1):51-4.
5
Randomised, double-blind, placebo-controlled trial of ditiocarb sodium ('Imuthiol') in human immunodeficiency virus infection.二硫卡钠（“免疫硫醇”）治疗人类免疫缺陷病毒感染的随机、双盲、安慰剂对照试验。
Lancet. 1988 Sep 24;2(8613):702-6. doi: 10.1016/s0140-6736(88)90184-5.
6
Inhibition of HIV progression by dithiocarb. German DTC Study Group.二硫代氨基甲酸盐对HIV进展的抑制作用。德国二硫代氨基甲酸盐研究小组。
Lancet. 1990 Mar 24;335(8691):679-82. doi: 10.1016/0140-6736(90)90802-c.
7
8
Effective therapy of the LP-BM5 murine retrovirus-induced lymphoproliferative immunodeficiency disease with diethyldithiocarbamate.用二乙基二硫代氨基甲酸盐有效治疗LP - BM5鼠逆转录病毒诱导的淋巴细胞增生性免疫缺陷病。
AIDS Res Hum Retroviruses. 1991 Jun;7(6):553-61. doi: 10.1089/aid.1991.7.553.
9
Biphasic toxicity of diethyldithiocarbamate, a metal chelation, to T lymphocytes and polymorphonuclear granulocytes: reversal by zinc and copper.金属螯合剂二乙基二硫代氨基甲酸盐对T淋巴细胞和多形核粒细胞的双相毒性：锌和铜的逆转作用
Biochem Biophys Res Commun. 1979 May 28;88(2):373-9. doi: 10.1016/0006-291x(79)92058-8.
Zotero 插件