Miyahara E, Takiyama W, Sakamoto N, Azuma T, Ohashi R, Kirihara Y, Doihara H, Yokoyama N, Tanada M, Soga H
Dept. of Surgery, Shikoku Cancer Center Hospital.
Gan To Kagaku Ryoho. 1993 Apr;20(5):643-6.
An experience with an advanced gastric cancer patient with metastases to bilateral breasts, uterus, abdominal lymph nodes, bilateral axillary and supraclavicular lymph nodes, and bone marrow, responded extremely well to an FAP combined chemotherapy as reported here. The patients received four courses of 5-FU (370 mg/m2/day, for five days, continuous infusion), ADM (30 mg/m2 on day 1, i.v.) and CDDP (55 mg/m2 on day 1, i.v.) every 3 weeks in our hospital. This was followed by 7 months of outpatient therapy with 5-FU (550 mg/m2 on day 1, i.v.), ADM (30 mg/m2 on day 1, i.v.) and CBDCA (330 mg/m2 on day 1, i.v.) for every 4 weeks. The complete remission of the primary and metastatic lesions, that was confirmed by the histological examinations, was obtained after 10 months since the initial treatment started. The toxicity was generally moderate, however, the alopecia was severe. The patient has been living for 6 months without any signs of the recurrence after the complete remission obtained.
本文报道了一名晚期胃癌患者，其癌细胞转移至双侧乳房、子宫、腹部淋巴结、双侧腋窝及锁骨上淋巴结和骨髓，接受FAP联合化疗后反应极佳。该患者在我院每3周接受4个疗程的5-氟尿嘧啶（370mg/m²/天，持续输注5天）、多柔比星（第1天30mg/m²，静脉注射）和顺铂（第1天55mg/m²，静脉注射）治疗。之后进行了7个月的门诊治疗，每4周使用5-氟尿嘧啶（第1天550mg/m²，静脉注射）、多柔比星（第1天30mg/m²，静脉注射）和卡铂（第1天330mg/m²，静脉注射）。自初始治疗开始10个月后，经组织学检查证实原发灶和转移灶完全缓解。毒性反应一般为中度，但脱发严重。患者在完全缓解后已存活6个月，无任何复发迹象。
