McCullagh M, MacConnachie I, Garvie D, Dykes E
Department of Paediatric Surgery, Children's Hospital, Lewisham, London.
Arch Dis Child Fetal Neonatal Ed. 1994 Sep;71(2):F111-3. doi: 10.1136/fn.71.2.f111.
A series of 13 consecutive patients with a prenatal diagnosis of congenital cystic adenomatoid malformation (CCAM) were reviewed with respect to prenatal ultrasound findings, clinical features at birth, and postnatal outcome. In two cases (15%) the abnormality regressed in utero. Only three infants (23%) showed any respiratory distress at birth. After a mean of 25 months postnatal follow up, 11 patients (85%) were found to have a definite pulmonary abnormality. In seven patients (54%) the specific prenatal diagnosis of CCAM has been confirmed (five histologically, two radiologically). Four infants (31%) were found to have other types of pulmonary abnormality and in two (15%) the lungs remain apparently normal. Prenatal ultrasound appears reliable in the detection of pulmonary abnormalities but the variety of conditions identified postnatally suggests that specific prenatal diagnoses and prognoses should be avoided; prenatal counselling and perinatal management should be adapted accordingly.
回顾了连续13例产前诊断为先天性囊性腺瘤样畸形（CCAM）的患者的产前超声检查结果、出生时的临床特征及产后结局。2例（15%）异常在子宫内消退。仅3例婴儿（23%）出生时出现任何呼吸窘迫。产后平均随访25个月后，11例患者（85%）被发现有明确的肺部异常。7例患者（54%）CCAM的产前特异性诊断得到证实（5例经组织学证实，2例经放射学证实）。4例婴儿（31%）被发现有其他类型的肺部异常，2例（15%）肺部似乎仍正常。产前超声在检测肺部异常方面似乎可靠，但产后发现的多种情况表明应避免进行特异性产前诊断和预后判断；产前咨询和围产期管理应相应调整。
