类风湿关节炎中的血清转铁蛋白受体
Serum transferrin receptors in rheumatoid arthritis.
作者信息
Zoli A, Altomonte L, Mirone L, Magaró M, Ricerca B M, Storti S, Candido A, Bizzi M
机构信息
Università Cattolica del Sacro Cuore, Rome, Italy.
出版信息
Ann Rheum Dis. 1994 Oct;53(10):699-701. doi: 10.1136/ard.53.10.699.
OBJECTIVE
Serum transferrin receptors (sTfR) were determined in patients affected by rheumatoid arthritis (RA) to verify a possible relationship with the degree of anaemia and with the severity of the inflammatory disease.
METHODS
sTfR, IL1-b, TNF-a and common parameters of iron metabolism were studied in 72 patients with active RA. Anaemia (Hb < 12 g/dl) was present in 51 patients. Twenty normal healthy subjects and 40 iron-deficient anaemic patients without chronic inflammatory, infective or malignant diseases were studied as controls.
RESULTS
In patients with RA sTfR levels were significantly higher than in the normal group but lower than in iron-deficient anaemic patients and correlated positively with ESR and IL1-b and negatively with Hb. Anaemic patients with RA were divided into two groups. Group A (56%) showed a possible iron deficiency (TSI < 16 and ferritin < 50 ng/ml); group B did not show iron deficiency (TSI > 16 and ferritin > 50 ng/ml). No significant difference in sTfR was observed in the two groups.
CONCLUSION
sTfR appear to be elevated and related to the degree of anaemia and to the inflammatory process in RA. Reduced sTfR levels in patients with RA compared with patients with iron-deficiency anaemia may indicate a reduced erythropoietic activity in RA.
目的
测定类风湿关节炎（RA）患者的血清转铁蛋白受体（sTfR），以验证其与贫血程度及炎症性疾病严重程度之间的可能关系。
方法
对72例活动期RA患者进行sTfR、白细胞介素1-β（IL1-β）、肿瘤坏死因子-α（TNF-α）及铁代谢常见参数的研究。51例患者存在贫血（血红蛋白<12 g/dl）。选取20名正常健康受试者及40例无慢性炎症、感染或恶性疾病的缺铁性贫血患者作为对照。
结果
RA患者的sTfR水平显著高于正常组，但低于缺铁性贫血患者，且与红细胞沉降率（ESR）和IL1-β呈正相关，与血红蛋白呈负相关。RA贫血患者分为两组。A组（56%）显示可能存在缺铁（转铁蛋白饱和度<16%且铁蛋白<50 ng/ml）；B组未显示缺铁（转铁蛋白饱和度>16%且铁蛋白>50 ng/ml）。两组的sTfR无显著差异。
结论
sTfR似乎升高，且与RA中的贫血程度及炎症过程相关。与缺铁性贫血患者相比，RA患者sTfR水平降低可能表明RA中红细胞生成活性降低。
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