Shah S S, Goldstraw P
Department of Thoracic Surgery, Royal Brompton National Heart and Lung Hospital, London, England.
Ann Thorac Surg. 1994 Nov;58(5):1452-6. doi: 10.1016/0003-4975(94)91934-8.
The technique first described by Monaldi has been modified for the treatment of discrete emphysematous bullae. Fifty-eight patients (median age, 56 years) underwent this procedure between 1983 and 1992. The operative mortality was 6.9% (4 patients). Fifty-two patients (89.6%) noted symptomatic improvement, as measured using the modified Medical Research Council of Great Britain dyspnea scale, from a mean value of 3.7 preoperatively to 2.1 postoperatively. Two patients remained unchanged symptomatically. In all patients, amelioration of symptoms was accompanied by an objective improvement in lung function. A mean increase of 28% was noted in the forced expiratory volume in 1 second (p < 0.05), and a 12.3% improvement in the total lung capacity was observed (p < 0.002). The residual lung volume-total lung capacity ratio declined from a mean of 70% to 57% after operation. A forced expiratory volume in 1 second of less than 500 mL (p < 0.05) and carbon dioxide tension of greater than 6.5 kPa (p < 0.05) were significant predictors of poor prognosis. The median follow-up period has been 1.9 years (range, 0.5 to 9 years). Two patients have returned for further drainage of new bullae on the operated side, and this was carried out percutaneously in both. We conclude that this technique offers a simple, safe, and effective method for the treatment of discrete bullous disease in patients with emphysema.
最初由莫纳尔迪描述的技术已被改良用于治疗局限性肺气肿大疱。1983年至1992年间,58例患者(中位年龄56岁)接受了该手术。手术死亡率为6.9%(4例患者)。52例患者(89.6%)症状有改善,采用改良的英国医学研究委员会呼吸困难量表评估,术前平均值为3.7,术后为2.1。2例患者症状无变化。所有患者症状改善的同时肺功能也有客观改善。一秒用力呼气量平均增加28%(p<0.05),肺总量改善12.3%(p<0.002)。术后残气量与肺总量之比从平均70%降至57%。一秒用力呼气量小于500 mL(p<0.05)和二氧化碳分压大于6.5 kPa(p<0.05)是预后不良的显著预测因素。中位随访期为1.9年(范围0.5至9年)。2例患者因手术侧出现新的大疱而回来进一步引流,均采用经皮引流。我们得出结论,该技术为治疗肺气肿患者的局限性大疱性疾病提供了一种简单、安全且有效的方法。