Maier U, Szabo N, Ludvik G
Department of Urology, University of Vienna Medical School, Austria.
Arch Androl. 1994 Jul-Aug;33(1):59-62. doi: 10.3109/01485019408987803.
After previous treatment failure using tamoxifen either alone or in combination with kallikrein, 25 patients with idiopathic oligoasthenoteratozoospermia (OAT syndrome) were subjected to 3 months of treatment with pentoxifylline at a dosage of 1200 mg/day. The only statistically significant (p < .008) improvement detected in the post-therapeutic spermiograms was an increase of normal forms. All other ejaculate parameters (density, motility, swelling test, penetration test) remained unchanged, and there was only one post-therapeutic pregnancy. It would appear the pentoxifylline after failure of established treatment modalities is not a therapy of choice in idiopathic OAT syndrome.
在先前单独使用他莫昔芬或与激肽释放酶联合治疗失败后，25例特发性少弱畸精子症（OAT综合征）患者接受了为期3个月的己酮可可碱治疗，剂量为每日1200毫克。治疗后的精液检查中唯一有统计学意义（p < 0.008）的改善是正常形态精子数量增加。所有其他射精参数（密度、活力、肿胀试验、穿透试验）均未改变，且治疗后仅有1例妊娠。看来，在既定治疗方式失败后，己酮可可碱并非特发性OAT综合征的首选治疗方法。
