Kayahara M, Murakami G, Adachi Y, Matsuno M, Adachi Y, Onoue Y, Iwaya M, Takayanagi M, Ikarashi T
Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University.
Arerugi. 1994 Jul;43(7):759-65.
Using histamine inhalation tests, we followed changes in bronchial hypersensitivity in 48 children with atopic dermatitis (AD) who were nonasthmatic on their initial visit. Twenty-three of these subjects became asthmatic during the follow-up period. The respiratory thresholds to histamine RT-Hist) of children with AD were widely distributed, ranging from 156 to more than 5000 micrograms/ml. There was a statistical difference in RT-Hist, as those who became asthmatic showed lower levels (< or = 625 micrograms/ml) at 2-6 yr of age. The percentage of peripheral eosinophil counts and IgE level was significantly elevated in those who became asthmatic. Subjects who developed asthma were more likely to have had positive D.p. RAST when they were less than 2 yr of age. The development of asthma in children with AD showed no significant relationship with family history of bronchial asthma.
通过组胺吸入试验，我们追踪了48例初诊时无哮喘的特应性皮炎（AD）患儿的支气管高敏反应变化。其中23例受试者在随访期间发展为哮喘。AD患儿的组胺呼吸阈值（RT-Hist）分布广泛，范围从156至超过5000微克/毫升。RT-Hist存在统计学差异，因为发展为哮喘的患儿在2至6岁时阈值较低（≤625微克/毫升）。外周嗜酸性粒细胞计数百分比和IgE水平在发展为哮喘的患儿中显著升高。发展为哮喘的受试者在2岁以下时更可能有阳性的粉尘螨RAST。AD患儿哮喘的发展与支气管哮喘家族史无显著关系。
