[哮喘儿童从首次就诊到缓解状态对组胺的支气管高敏反应纵向研究]

[Bronchial hypersensitivity to histamine in asthmatic children longitudinal study from first visit to remitted state].

作者信息

Kayahara M, Murakami G, Adachi Y, Matsuno M, Adachi Y, Onoue Y, Iwaya M, Takayanagi M, Ikarashi T

机构信息

Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University.

出版信息

Arerugi. 1994 Jul;43(7):766-72.

PMID:7980016

Abstract

In order to examine the changes in bronchial hypersensitivity, histamine inhalation tests were evaluated in 27 asthmatic children who remitted. The respiratory threshold to histamine (RT-Hist) 2-3 yrs after remission was higher than in the initial test, in their worst periods of the asthma and just before remission (p < 0.001, p < 0.001, p < 0.005, respectively). Eleven subjects (40.7%), showed no improvement of bronchial hypersensitivity 2-3 yrs after remission (RT-Hist was 1250 micrograms/ml or lower). In this group, the asthma score per year two and three years before symptom-free state was higher than in the group with improved bronchial hypersensitivity (p < 0.05). There was no significant difference between % fall of FEV1.0 in RT-Hist in the worst periods of the asthma and 2-3 yrs after remission. FEV1.0/VCP, %V50, %V25 and V25/Ht 2-3 yrs after remission were higher than those in the worst periods of the asthma.

摘要

为了研究支气管高反应性的变化，对27名病情缓解的哮喘儿童进行了组胺吸入试验评估。缓解后2 - 3年的组胺呼吸阈值（RT-Hist）高于哮喘最严重期及缓解前初始试验时的水平（分别为p < 0.001、p < 0.001、p < 0.005）。11名受试者（40.7%）在缓解后2 - 3年支气管高反应性未改善（RT-Hist为1250微克/毫升或更低）。在该组中，无症状状态前两年和三年的每年哮喘评分高于支气管高反应性改善组（p < 0.05）。哮喘最严重期的RT-Hist中FEV1.0下降百分比与缓解后2 - 3年之间无显著差异。缓解后2 - 3年的FEV1.0/VCP、%V50、%V25和V25/Ht高于哮喘最严重期。