Avtandilov G G, Barsukov V S
Arkh Patol. 1993 Jan-Feb;55(1):7-12.
Immune and endocrine organs of 259 children and adults who had died of sepsis, local purulent-inflammatory affections were studied morphologically and morphometrically. It is established, that compensatory morphological changes in the lymphoid tissue and endocrine organs are integrated into a united system the structural basis of which are numerous inter- and intra-organ correlations. A systemic interaction between the lymphoid and endocrine organs at early age is pronounced much weaker than in the adults. A progressive destruction of this systemic interaction takes place in sepsis and results in an increase of informational entropy and the coefficient of the system disintegration. Inability of the body to fight bacteremia and to localize the infection is secondary to the system destruction this being due to high frequency of previous immuno-endocrinopathies.
对259名死于败血症、局部化脓性炎症的儿童和成人的免疫和内分泌器官进行了形态学和形态计量学研究。已确定，淋巴组织和内分泌器官的代偿性形态学变化整合为一个统一的系统，其结构基础是器官间和器官内的众多相关性。幼年时淋巴器官和内分泌器官之间的系统性相互作用明显比成人弱。败血症时这种系统性相互作用会逐渐遭到破坏，导致信息熵增加和系统解体系数增大。机体无法抵抗菌血症和定位感染是系统破坏的继发结果，这是由于既往免疫内分泌病的高发率所致。
