Kaufmann R, Reul H, Rau G
Helmholtz-Institute for Biomedical Engineering, RWTH, Aachen, Germany.
Artif Organs. 1994 Jul;18(7):537-42. doi: 10.1111/j.1525-1594.1994.tb03374.x.
To perform the first experimental tests for validation of a new gear unit concept, the pump chamber, diaphragm, and pusher plate design of an orthotopic electromechanical total artificial heart (TAH) (Helmholtz Labtype) was manufactured. In its early stage of development, it provides some of the most important features of the conceptual final artificial heart. The new gear unit transforms a uniform unidirectional rotational motor movement into translatory pusher plate movements, with resting phase in the end-diastolic position, and the angled pump chamber orientation determines the available space for the motor and gear unit. Furthermore, this labtype provides flexibility with regard to use of different types of structural parts for experimental investigations. The first in vitro test results, obtained with specially designed circulatory mockloops that simulate physiological preload and afterload conditions, are presented. They comprise pressure and flow generation, motor performance, efficiency, and energy consumption. The results prove the feasibility of the new gear unit concept for an electromechanical artificial heart and allow a reliable determination of the necessary performance of the future brushless DC motor for the first in vivo TAH model.
为了对一种新的齿轮装置概念进行首次实验测试以验证其有效性，制造了一种原位机电式全人工心脏（TAH）（亥姆霍兹实验室型）的泵腔、隔膜和推板设计。在其早期开发阶段，它具备了概念性最终人工心脏的一些最重要特征。这种新的齿轮装置将均匀的单向旋转电机运动转化为推板的平移运动，在舒张末期位置有静止阶段，并且泵腔的倾斜方向决定了电机和齿轮装置的可用空间。此外，这种实验室型在用于实验研究的不同类型结构部件的使用方面提供了灵活性。展示了通过专门设计的模拟生理预负荷和后负荷条件的循环模拟回路获得的首次体外测试结果。这些结果包括压力和流量产生、电机性能、效率以及能量消耗。结果证明了新的齿轮装置概念用于机电式人工心脏的可行性，并为首个体内TAH模型的未来无刷直流电机的必要性能提供了可靠的测定依据。
