Michael J C, de Venecia G, Bresnick G H
Department of Ophthalmology, University of Wisconsin-Madison Medical School.
Arch Ophthalmol. 1994 Nov;112(11):1455-9. doi: 10.1001/archopht.1994.01090230069022.
Macular heterotopia secondary to proliferative diabetic retinopathy has been previously reported in clinical cases. To our knowledge, we present the first clinicopathologic case of macular heterotopia in a young patient with proliferative diabetic retinopathy. The significant pathologic findings included dense fibrovascular tissue on the disc to correspond with nasal tractional retinal detachment, a superonasally displaced fovea, and an area of stripped and recoiled internal limiting membrane overlying a retinal fold. In addition, an area of reduplicated retinal pigment epithelium was noted corresponding to the clinically observed hyperpigmented area superior to the heterotopic fovea. Despite the pathologic changes, the patient maintained 20/40 visual acuity with the heterotopic fovea for several years. The findings are discussed in relation to previous clinical studies.
黄斑异位继发于增殖性糖尿病视网膜病变，此前已在临床病例中有报道。据我们所知，我们报告了首例年轻增殖性糖尿病视网膜病变患者黄斑异位的临床病理病例。显著的病理表现包括视盘上致密的纤维血管组织，与鼻侧牵拉性视网膜脱离相符，中央凹超鼻侧移位，以及视网膜皱褶上方有一层剥离并回缩的内界膜区域。此外，在与临床观察到的位于异位中央凹上方的色素沉着区域相对应处，发现了一层重复的视网膜色素上皮。尽管有病理改变，但该患者异位中央凹的视力多年来一直维持在20/40。本文结合既往临床研究对这些发现进行了讨论。
