Takeuchi M, Kakushi H, Tohkin M
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Biochem Biophys Res Commun. 1994 Oct 28;204(2):905-11. doi: 10.1006/bbrc.1994.2545.
5 alpha-Dihydrotestosterone (DHT), an active form of testosterone, was shown to stimulate the mineralization of osteoblasts in a time- and dose-dependent manner in vitro in the presence of inorganic phosphate, as well as transforming growth factor beta and 1 alpha, 25 dihydroxyvitamin D3. However, DHT, stimulated the mineralization by a different mechanism from that of transforming growth factor beta and 1 alpha, 25 dihydroxyvitamin D3. We found that DHT increased the number of androgen receptors. These findings suggest that androgens directly stimulate mineralization in osteoblasts associated with an increase in the number of their receptors.
5α-双氢睾酮（DHT）是睾酮的一种活性形式，研究表明，在无机磷酸盐、转化生长因子β以及1α,25-二羟基维生素D3存在的情况下，DHT在体外能以时间和剂量依赖的方式刺激成骨细胞矿化。然而，DHT刺激矿化的机制与转化生长因子β和1α,25-二羟基维生素D3不同。我们发现DHT增加了雄激素受体的数量。这些发现表明，雄激素通过增加其受体数量直接刺激成骨细胞矿化。
