Ben-Chetrit A, Ben-Chetrit E
Shaare Zedek Medical Center, Jerusalem, Israel.
Arthritis Rheum. 1994 Nov;37(11):1614-7. doi: 10.1002/art.1780371109.
Infertile women are treated with various regimens for ovulation induction. The ultimate end-result of these treatments is a significant rise in levels of serum gonadotropins and estradiol--the most potent natural estrogen. Estrogens may affect diverse biologic functions, including immune and inflammatory reactions. A role for estrogens in the development or exacerbation of systemic lupus erythematosus (SLE) has been suggested by many studies. In this report, we present 3 cases of otherwise healthy women who received ovulation induction agents and subsequently developed full-blown SLE. The possible association between this treatment and SLE is discussed.
不孕女性会接受各种诱导排卵的治疗方案。这些治疗的最终结果是血清促性腺激素和雌二醇（最有效的天然雌激素）水平显著升高。雌激素可能会影响多种生物学功能，包括免疫和炎症反应。许多研究表明雌激素在系统性红斑狼疮（SLE）的发生或加重中起作用。在本报告中，我们介绍了3例原本健康的女性，她们接受了诱导排卵药物治疗，随后发展为典型的SLE。本文讨论了这种治疗与SLE之间可能存在的关联。
