Morita A, Kimura M, Itokawa Y
Department of Environmental Medicine, Graduate School of Medicine, Kyoto University, Japan.
Biol Trace Elem Res. 1994 Aug;42(2):165-77. doi: 10.1007/BF02785387.
To clarify the effect of aging on the mineral status of female mice, mineral concentrations in their tissues were determined. Five 2-mo-old, five 6-mo-old, and five 10-mo-old female B10BR mice were fed a commercial diet. Iron, zinc, copper, calcium, magnesium, sodium, and potassium concentrations in the blood, liver, kidney, heart, brain, lung, and spleen of the mice were determined using a flame atomic absorption spectrophotometer. Iron concentrations in the liver, kidney, heart, brain, and spleen increased with age. Significant differences were detected between mice 2 and 6 mo of age and between mice 2 and 10 mo of age. Zinc concentrations in the heart and lung decreased significantly with age. Zinc concentrations in the heart and lung of 10-mo-old mice were significantly lower than those of 2-mo-old mice. It is noteworthy that the copper concentration in the brain of 10-mo-old mice was markedly higher compared with that of younger mice. Calcium accumulation was apparent in the kidney of mice at 10 mo.
为阐明衰老对雌性小鼠矿物质状态的影响，测定了其组织中的矿物质浓度。给五只2月龄、五只6月龄和五只10月龄的雌性B10BR小鼠喂食商业饲料。使用火焰原子吸收分光光度计测定小鼠血液、肝脏、肾脏、心脏、大脑、肺和脾脏中的铁、锌、铜、钙、镁、钠和钾浓度。肝脏、肾脏、心脏、大脑和脾脏中的铁浓度随年龄增长而增加。在2月龄和6月龄小鼠之间以及2月龄和10月龄小鼠之间检测到显著差异。心脏和肺中的锌浓度随年龄增长显著降低。10月龄小鼠心脏和肺中的锌浓度显著低于2月龄小鼠。值得注意的是，10月龄小鼠大脑中的铜浓度明显高于年轻小鼠。10月龄小鼠的肾脏中明显出现钙积累。
