长春西汀与奥沙西泮之间不存在药代动力学相互作用。
Lack of pharmacokinetic interaction between vinpocetine and oxazepam.
作者信息
Storm G, Oosterhuis B, Sollie F A, Visscher H W, Sommer W, Beitinger H, Jonkman J H
机构信息
Pharma Bio-Research International B.V., Zuidlaren, The Netherlands.
出版信息
Br J Clin Pharmacol. 1994 Aug;38(2):143-6. doi: 10.1111/j.1365-2125.1994.tb04338.x.
The influence of multiple doses of vinpocetine (10 mg three times daily) on the steady state plasma concentrations of oxazepam (10 mg three times daily) was studied in 16 healthy subjects. The mean (+/- s.d.) AUC (ng ml-1h-1) of oxazepam over 24 h during combined treatment was 4716 +/- 2296 and for oxazepam treatment alone it was 4737 +/- 2448 (95% confidence intervals for ratio of means = 95.4-103.7%). The degree of plasma protein binding of oxazepam was 98.11 +/- 0.32% and was not affected by vinpocetine. Independent of vinpocentine treatment a significant diurnal change in the plasma binding of oxazepam was observed; the free drug fraction was 20% higher during the night than during the day. Cmax and AUC values based on total oxazepam in plasma were 10% lower during the night. The results indicate a lack of influence of vinpocetine on oxazepam kinetics. Diurnal changes in the plasma binding of oxazepam probably have no clinical consequences.
在16名健康受试者中研究了多次服用长春西汀（每日3次，每次10mg）对奥沙西泮（每日3次，每次10mg）稳态血药浓度的影响。联合治疗期间奥沙西泮24小时的平均（±标准差）AUC（ng/ml·h）为4716±2296，单独使用奥沙西泮治疗时为4737±2448（均值比的95%置信区间=95.4-103.7%）。奥沙西泮的血浆蛋白结合率为98.11±0.32%，不受长春西汀影响。与长春西汀治疗无关，观察到奥沙西泮血浆结合存在显著的昼夜变化；夜间游离药物分数比白天高20%。基于血浆中总奥沙西泮的Cmax和AUC值在夜间低10%。结果表明长春西汀对奥沙西泮动力学无影响。奥沙西泮血浆结合的昼夜变化可能无临床意义。
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