Nagahama Y
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki, Japan.
Int J Dev Biol. 1994 Jun;38(2):217-29.
The pituitary-gonadal axis plays an important role in regulating gametogenesis in vertebrates. In most cases, gonadotropins act through the biosynthesis of gonadal steroid hormones which in turn mediate various stages of gametogenesis. A series of studies in our laboratory using several species of teleost fishes as experimental animals has provided new information about the endocrine regulation of gametogenesis, including oocyte growth, oocyte maturation, spermatogenesis and sperm maturation. This article briefly reviews our findings on the identification of steroidal mediators involved in each process of gametogenesis, and the sites and mechanisms of action of the mediators. These observations collectively demonstrate the appropriateness of using teleost fishes as valid models for examining hormonal influences on gametogenesis. Such models could also have applications and validity for vertebrates in general.
垂体 - 性腺轴在调节脊椎动物配子发生过程中发挥着重要作用。在大多数情况下，促性腺激素通过性腺甾体激素的生物合成起作用，而性腺甾体激素反过来介导配子发生的各个阶段。我们实验室利用几种硬骨鱼类作为实验动物进行的一系列研究，为配子发生的内分泌调节提供了新信息，包括卵母细胞生长、卵母细胞成熟、精子发生和精子成熟。本文简要回顾了我们在识别参与配子发生各过程的甾体介质以及这些介质的作用位点和机制方面的研究结果。这些观察结果共同证明了将硬骨鱼类用作研究激素对配子发生影响的有效模型的合理性。这样的模型对一般脊椎动物也可能具有适用性和有效性。
