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早期B淋巴细胞分化过程中白细胞介素-2受体α链的表达

IL-2 receptor alpha chain expression during early B lymphocyte differentiation.

作者信息

Chen J, Ma A, Young F, Alt F W

机构信息

Howard Hughes Medical Institute, Boston, MA.

出版信息

Int Immunol. 1994 Aug;6(8):1265-8. doi: 10.1093/intimm/6.8.1265.

DOI:10.1093/intimm/6.8.1265
PMID:7981152
Abstract

The IL-2/IL-2 receptor (IL-2R) has been studied intensively because of its potential function in the development and regulation of the immune system. The IL-2R alpha chain has been shown to be expressed on CD4-CD8- thymocytes and activated T and B cells. In this report, we show that IL-2R alpha is also expressed on precursor B cells in the bone marrow. Its expression is initiated by functional rearrangement and expression of Ig mu heavy chain gene and is down-regulated when immature B cells mature and express IgD. Its potential function in early B cell differentiation is discussed in comparison with its role in thymocyte differentiation.

摘要

白细胞介素-2/白细胞介素-2受体（IL-2R）因其在免疫系统发育和调节中的潜在功能而受到深入研究。IL-2Rα链已被证明在CD4-CD8-胸腺细胞以及活化的T细胞和B细胞上表达。在本报告中，我们表明IL-2Rα也在骨髓中的前体B细胞上表达。其表达由Igμ重链基因的功能性重排和表达启动，当未成熟B细胞成熟并表达IgD时下调。与它在胸腺细胞分化中的作用相比，讨论了其在早期B细胞分化中的潜在功能。

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