[Interaction of rat myocardial tissue with nitroxide radicals].

Interaction of myocardium with nitroxide radicals (TEMPO, TEMPAMINE and TEMPOL) has been studied on the experimental model of Langendorf-perfused rat heart. Freezing of radical-containing hearts has been performed during their perfusion or after 40-min total ischemia. It has been shown that all the analyzed radicals are localized in lipid microenvironment in myocardium. Molecules of TEMPAMINE and TEMPOL are more immobilized, than TEMPO ones. It has been shown, that there are no changes in the microenvironment of the radicals and the character of their mobility in myocardium, caused by ischemia.