Timoshin A A, Ruuge E K
Biofizika. 1994 Jul-Aug;39(4):709-12.
Interaction of myocardium with nitroxide radicals (TEMPO, TEMPAMINE and TEMPOL) has been studied on the experimental model of Langendorf-perfused rat heart. Freezing of radical-containing hearts has been performed during their perfusion or after 40-min total ischemia. It has been shown that all the analyzed radicals are localized in lipid microenvironment in myocardium. Molecules of TEMPAMINE and TEMPOL are more immobilized, than TEMPO ones. It has been shown, that there are no changes in the microenvironment of the radicals and the character of their mobility in myocardium, caused by ischemia.
在Langendorf灌注大鼠心脏实验模型上研究了心肌与氮氧自由基（TEMPO、TEMPAMINE和TEMPOL）的相互作用。含自由基的心脏在灌注过程中或40分钟完全缺血后进行冷冻。结果表明，所有分析的自由基都定位于心肌的脂质微环境中。与TEMPO分子相比，TEMPAMINE和TEMPOL分子的固定性更强。结果表明，缺血并未导致心肌中自由基微环境及其移动特性发生变化。
