[在灌注正常氧合的无底物溶液过程中分离的大鼠心肌中的自由基中心]
[Free radical centers in isolated rat myocardium during perfusion with the normally oxygenated substrate-free solution].
作者信息
Timoshin A A, Lakomkin V L, Ruuge E K
出版信息
Biofizika. 1996 Nov-Dec;41(6):1305-8.
PMID:9044626
Abstract
EPR spectroscopy was used to measure free radical species of samples of working rat hearts freeze-clamped during their perfusion under normal conditions as well as using the substrate-free solution. It has been obtained that the transition to the substrate-free state results in decreasing of concentration of flavosemiquinones in the tissue which causes: the changes in spectral and relaxational characteristics of EPR spectra of the samples and 1,3-fold decrease of the content of free radical centers in myocardium.
摘要
电子顺磁共振光谱法用于测量正常条件下灌注以及使用无底物溶液时冷冻钳夹的工作大鼠心脏样本中的自由基种类。结果表明，转变为无底物状态会导致组织中黄素半醌浓度降低，这会引起：样本电子顺磁共振光谱的光谱和弛豫特性发生变化，以及心肌中自由基中心含量降低1.3倍。
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