Grange A O, Santosham M, Ayodele A K, Lesi F E, Stallings R Y, Brown K H
Department of Pediatrics, College of Medicine, University of Lagos Teaching Hospital, Nigeria.
Acta Paediatr. 1994 Aug;83(8):825-32. doi: 10.1111/j.1651-2227.1994.tb13153.x.
A randomized clinical trial was carried out to compare a locally available maize-cowpea-palm oil diet (group MCP) with a commercially produced lactose-free, soy protein isolate formula (group SF) for the dietary management of 69 Nigerian boys, 6-24 months of age, hospitalized for acute, watery diarrhea. Although the treatment groups were generally similar initially, the children in group SF had slightly lower mean weight-for-age z scores (p = 0.08), lower serum bicarbonate levels (p = 0.04) and greater stool outputs during the period of rehydration before the diets were initiated (p = 0.01). Rates of treatment failure in group MCP (5.7%) and group SF (8.8%) were similar (p = 0.67). There were no significant differences in the adjusted mean stool outputs by study group on days 1-5, but the children in group SF had slightly lower fecal weights on day 6 (p = 0.05). Children in group MCP had a substantially reduced duration of liquid stool excretion (estimated median duration 42 h versus 140 h; p < 0.001). On the other hand, children in group SF consumed considerably more of their diet, had greater net absorption of macronutrients and greater rates of weight gain than those in group MCP. We conclude that children can safely consume the MCP diet during acute, watery diarrhea without increasing their risk of treatment failure or augmenting stool output. However, the diet may not be adequate as a sole source of nutrients beyond the period of acute illness.
开展了一项随机临床试验，比较当地可得的玉米-豇豆-棕榈油饮食（MCP组）与市售的无乳糖大豆分离蛋白配方奶粉（SF组）对69名6至24个月大因急性水样腹泻住院的尼日利亚男孩的饮食管理效果。尽管治疗组最初总体相似，但SF组儿童的年龄别体重Z评分略低（p = 0.08），血清碳酸氢盐水平较低（p = 0.04），且在开始饮食前的补液期间大便量较多（p = 0.01）。MCP组（5.7%）和SF组（8.8%）的治疗失败率相似（p = 0.67）。研究组在第1至5天调整后的平均大便量无显著差异，但SF组儿童在第6天的粪便重量略低（p = 0.05）。MCP组儿童的液体粪便排泄持续时间大幅缩短（估计中位持续时间为42小时对140小时；p < 0.001）。另一方面，SF组儿童的饮食摄入量明显更多，宏量营养素的净吸收量更大，体重增加率也高于MCP组。我们得出结论，儿童在急性水样腹泻期间可安全食用MCP饮食，而不会增加治疗失败风险或增加大便量。然而，在急性疾病期之后，该饮食作为唯一营养来源可能并不充足。
