Brown K H, Perez F, Peerson J M, Fadel J, Brunsgaard G, Ostrom K M, MacLean W C
Department of Nutrition, University of California, Davis 95616-8669.
Pediatrics. 1993 Aug;92(2):241-7.
To assess the effects of dietary fiber (soy polysaccharide) on the severity, duration, and nutritional outcome of acute, watery childhood diarrhea.
A total of 34 hospitalized Peruvian male infants between 2 and 24 months of age were randomly assigned to receive a soy-protein isolate, lactose-free formula with added soy polysaccharide (group SF, n = 19) or the same diet without added fiber (group S, n = 15). The consumption of formulas, stool amount and consistency, absorption of macronutrients, and change in anthropometric status were measured.
Children in both groups were initially similar with regard to age, nutritional status, and prior duration and severity of diarrhea. Four patients in group SF (21%) and two in group S (13%) failed therapy because of recurrent dehydration or severe purging (P = .67). Formula intakes increased slightly during hospitalization (P = .03), but did not vary by dietary group (P = .73). Stool outputs declined significantly (P < .001) during hospitalization, but there were no significant differences by dietary group in either stool wet weight (P = .83) or dry weight (P = .87). Estimated median durations of liquid stool excretion after hospitalization were 43 hours in group SF and 163 hours in group S (P = .003). There were no significant differences in fractional or net absorption of macronutrients or change in anthropometric status by dietary group.
Soy polysaccharide, while not affecting stool output, macronutrient absorption, or nutritional status during acute, watery childhood diarrhea, significantly and markedly reduced the duration of liquid stool excretion.
评估膳食纤维（大豆多糖）对儿童急性水样腹泻的严重程度、持续时间及营养结局的影响。
共34名年龄在2至24个月之间的秘鲁住院男婴被随机分配，分别接受添加了大豆多糖的大豆分离蛋白无乳糖配方奶粉（SF组，n = 19）或不含添加纤维的相同饮食（S组，n = 15）。测量配方奶粉的摄入量、粪便量及稠度、常量营养素的吸收情况以及人体测量状况的变化。
两组儿童在年龄、营养状况以及腹泻的既往持续时间和严重程度方面最初相似。SF组有4名患者（21%），S组有2名患者（13%）因反复脱水或严重腹泻而治疗失败（P = 0.67）。住院期间配方奶粉摄入量略有增加（P = 0.03），但不同饮食组之间无差异（P = 0.73）。住院期间粪便排出量显著下降（P < 0.001），但不同饮食组在粪便湿重（P = 0.83）或干重（P = 0.87）方面均无显著差异。住院后估计的液体粪便排泄中位持续时间，SF组为43小时，S组为163小时（P = 0.003）。不同饮食组在常量营养素的分数吸收或净吸收以及人体测量状况变化方面无显著差异。
大豆多糖在儿童急性水样腹泻期间虽不影响粪便排出量、常量营养素吸收或营养状况，但能显著且明显缩短液体粪便排泄的持续时间。
