Llovera M, García-Martínez C, López-Soriano F J, Argilés J M
Departament de Bioquímica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, Spain.
Biochem Mol Biol Int. 1994 Jul;33(4):681-9.
Chronic tumour necrosis factor-alpha (TNF) treatment of rats for 4 days resulted in transient decreases in food intake and body weight, 24 h after the beginning of the cytokine treatment. Treatment with the cytokine resulted in a large increase in circulating urea concentrations. The urinary excretion of urea and creatinine is increased following TNF treatment. 3-methylhistidine, an indicator of contractile protein breakdown, is also elevated in the urine of the animals treated with the cytokine. From previous observations (1) and the data presented here, it is suggested that TNF enhanced muscle catabolism even in experimental situations were body weight loss was not apparent.
对大鼠进行4天的慢性肿瘤坏死因子-α（TNF）治疗，在细胞因子治疗开始24小时后，导致食物摄入量和体重短暂下降。细胞因子治疗导致循环尿素浓度大幅增加。TNF治疗后尿素和肌酐的尿排泄量增加。3-甲基组氨酸是收缩蛋白分解的指标，在用细胞因子治疗的动物尿液中也升高。根据先前的观察结果（1）和此处呈现的数据，表明即使在体重减轻不明显的实验情况下，TNF也会增强肌肉分解代谢。
