Mello A M, Isaacs R, Petersen J, Kronenberger S, McDougall I R
Department of Radiology, Stanford University, California.
Clin Nucl Med. 1994 Sep;19(9):776-81. doi: 10.1097/00003072-199409000-00006.
Metastatic papillary carcinoma was diagnosed in a 42-year-old woman. The cancer had invaded out of the gland and was present in many lymph nodes. After her surgical procedure, she was advised to have radioiodine. However, the patient had total renal failure and was on dialysis. Studies were carried out using a tracer dose of 2 mCi of radioiodine, demonstrating that approximately 60% of the radioactivity in the body was removed with each dialysis. Calculations indicated that a meaningful dose of radiation could be delivered to residual thyroid and metastases with 100 mCi of radioiodine and the total body radiation would be < 100 rad delivered over several days. Based on these analyses, she received 100 mCi of I-131 on two separate occasions and on follow-up scan, clinical evaluation and thyroglobulin measurement is free of disease.
一名42岁女性被诊断为转移性乳头状癌。癌症已侵犯腺体外，并存在于多个淋巴结中。手术后，建议她进行放射性碘治疗。然而，该患者出现了完全肾衰竭并正在接受透析。使用2毫居里放射性碘的示踪剂量进行研究，结果表明每次透析可清除体内约60%的放射性。计算表明，给予100毫居里放射性碘可向残留甲状腺和转移灶输送有意义的辐射剂量，且在数天内全身辐射剂量将<100拉德。基于这些分析，她分两次接受了100毫居里的I-131治疗，随访扫描、临床评估和甲状腺球蛋白测量均显示无疾病迹象。
