Lavy A, Mates A
Mycobacterium Reference Laboratory, A. Felix Public Health Laboratories, Tel Aviv, Israel.
Isr J Med Sci. 1994 Nov;30(11):805-10.
An increased incidence of tuberculosis has been observed in Israel in 1985, 1986 and since 1990--years of large waves of immigrations. A very similar trend of disease was observed in the Mycobacterium Reference Laboratory of Israel, and consequently a survey was undertaken among the 1,181 bacteriologically confirmed tuberculosis cases newly registered there in 1983-92. The overall percent distribution of drug-resistant Mycobacterium tuberculosis during this period was 12.6% (7.3% resistant to one drug and 5.3% (multiple drug resistance). The highest percent distribution of drug-resistant bacilli was found among immigrants from the former Soviet Union (37.3%) and Ethiopia (16.2%). The highest incidence of disease was found in males and in patients aged > 30. Pulmonary disease was the most common form for all patients: among the extrapulmonary cases, the most frequently involved site was the genitourinary system in Israelis and the lymph nodes in Ethiopians. Most isolates fit into one variant by biochemical analysis, indicating the need for a more sensitive method to type M. tuberculosis for epidemiological purposes. The data included in this survey provide information useful for a national tuberculosis program.
1985年、1986年以及自1990年以来（大规模移民浪潮的年份），以色列的结核病发病率有所上升。以色列分枝杆菌参考实验室也观察到了非常相似的疾病趋势，因此对1983 - 1992年在该实验室新登记的1181例经细菌学确诊的结核病病例进行了一项调查。在此期间，耐药结核分枝杆菌的总体百分比分布为12.6%（7.3%对一种药物耐药，5.3%多重耐药）。耐药杆菌百分比分布最高的是来自前苏联的移民（37.3%）和埃塞俄比亚移民（16.2%）。疾病发病率最高的是男性以及年龄大于30岁的患者。肺部疾病是所有患者中最常见的形式：在肺外病例中，以色列人最常受累的部位是泌尿生殖系统，埃塞俄比亚人则是淋巴结。通过生化分析，大多数分离株属于一个变种，这表明需要一种更灵敏的方法对结核分枝杆菌进行分型以用于流行病学目的。本次调查所包含的数据为国家结核病规划提供了有用信息。
