用棉尾兔乳头瘤病毒的非结构蛋白E1和E2进行免疫可刺激病毒诱导的乳头瘤消退。
Immunization with nonstructural proteins E1 and E2 of cottontail rabbit papillomavirus stimulates regression of virus-induced papillomas.
作者信息
Selvakumar R, Borenstein L A, Lin Y L, Ahmed R, Wettstein F O
机构信息
Department of Microbiology and Immunology, School of Medicine, University of California, Los Angeles 90024-1747.
出版信息
J Virol. 1995 Jan;69(1):602-5. doi: 10.1128/JVI.69.1.602-605.1995.
Abstract
Cottontail rabbit papillomavirus is the major animal model for cancer-associated papillomaviruses. Here we show that vaccination with the nonstructural proteins E1 and E2 induces the regression of virus-induced papillomas and that vaccination is equally effective when proteins are given with and without adjuvant. There was no correlation between antibody levels and regression, suggesting that tumor regression may be due to a cell-mediated response.
摘要
棉尾兔乳头瘤病毒是与癌症相关的乳头瘤病毒的主要动物模型。在此我们表明，用非结构蛋白E1和E2进行疫苗接种可诱导病毒诱导的乳头瘤消退，并且无论是否使用佐剂给予蛋白，疫苗接种的效果都是相同的。抗体水平与消退之间没有相关性，这表明肿瘤消退可能是由于细胞介导的反应。
相似文献
1
Immunization with nonstructural proteins E1 and E2 of cottontail rabbit papillomavirus stimulates regression of virus-induced papillomas.用棉尾兔乳头瘤病毒的非结构蛋白E1和E2进行免疫可刺激病毒诱导的乳头瘤消退。
J Virol. 1995 Jan;69(1):602-5. doi: 10.1128/JVI.69.1.602-605.1995.
2
Tumor regression is associated with a specific immune response to the E2 protein of cottontail rabbit papillomavirus.肿瘤消退与针对棉尾兔乳头瘤病毒E2蛋白的特异性免疫反应相关。
Virology. 1995 Apr 1;208(1):298-302. doi: 10.1006/viro.1995.1152.
3
Changes in RNA expression pattern during the malignant progression of cottontail rabbit papillomavirus-induced tumors in rabbits.棉尾兔乳头瘤病毒诱导的兔肿瘤恶性进展过程中RNA表达模式的变化。
J Virol. 1994 Jun;68(6):3620-30. doi: 10.1128/JVI.68.6.3620-3630.1994.
4
Granulocyte-macrophage colony-stimulating factor priming plus papillomavirus E6 DNA vaccination: effects on papilloma formation and regression in the cottontail rabbit papillomavirus--rabbit model.粒细胞-巨噬细胞集落刺激因子预刺激加乳头瘤病毒E6 DNA疫苗接种：对棉尾兔乳头瘤病毒-兔模型中乳头瘤形成和消退的影响
J Virol. 2000 Sep;74(18):8700-8. doi: 10.1128/jvi.74.18.8700-8708.2000.
5
Immunization of rabbits with cottontail rabbit papillomavirus E1 and E2 genes: protective immunity induced by gene gun-mediated intracutaneous delivery but not by intramuscular injection.用棉尾兔乳头瘤病毒E1和E2基因免疫兔子：基因枪介导的皮内接种可诱导保护性免疫，而肌肉注射则不能。
Vaccine. 2000 Jul 1;18(26):2937-44. doi: 10.1016/s0264-410x(00)00110-9.
6
Regression of papillomas induced by cottontail rabbit papillomavirus is associated with infiltration of CD8+ cells and persistence of viral DNA after regression.棉尾兔乳头瘤病毒诱导的乳头瘤消退与CD8 +细胞浸润及消退后病毒DNA的持续存在有关。
J Virol. 1997 Jul;71(7):5540-8. doi: 10.1128/JVI.71.7.5540-5548.1997.
7
Vaccination of rabbits with an adenovirus vector expressing the papillomavirus E2 protein leads to clearance of papillomas and infection.用表达乳头瘤病毒E2蛋白的腺病毒载体对兔子进行疫苗接种可导致乳头瘤和感染的清除。
J Virol. 2004 Jan;78(1):116-23. doi: 10.1128/jvi.78.1.116-123.2004.
8
Recombinant Listeria monocytogenes vaccination eliminates papillomavirus-induced tumors and prevents papilloma formation from viral DNA.重组单核细胞增生李斯特菌疫苗接种可消除乳头瘤病毒诱导的肿瘤，并防止由病毒DNA形成乳头瘤。
J Virol. 1997 Nov;71(11):8467-74. doi: 10.1128/JVI.71.11.8467-8474.1997.
9
Intracutaneous DNA vaccination with the E8 gene of cottontail rabbit papillomavirus induces protective immunity against virus challenge in rabbits.用棉尾兔乳头瘤病毒E8基因进行皮内DNA疫苗接种可诱导兔产生针对病毒攻击的保护性免疫。
J Virol. 2002 Jul;76(13):6453-9. doi: 10.1128/jvi.76.13.6453-6459.2002.
10
A transactivator function of cottontail rabbit papillomavirus e2 is essential for tumor induction in rabbits.棉尾兔乳头瘤病毒E2的反式激活功能对于在兔体内诱导肿瘤至关重要。
J Virol. 2002 Nov;76(22):11209-15. doi: 10.1128/jvi.76.22.11209-11215.2002.
引用本文的文献
1
The rabbit papillomavirus model: a valuable tool to study viral-host interactions.兔乳头瘤病毒模型：研究病毒-宿主相互作用的有价值工具。
Philos Trans R Soc Lond B Biol Sci. 2019 May 27;374(1773):20180294. doi: 10.1098/rstb.2018.0294.
2
Recent advances in preclinical model systems for papillomaviruses.乳头瘤病毒临床前模型系统的最新进展。
Virus Res. 2017 Mar 2;231:108-118. doi: 10.1016/j.virusres.2016.12.004. Epub 2016 Dec 9.
3
Using HLA-A2.1 Transgenic Rabbit Model to Screen and Characterize New HLA-A2.1 Restricted Epitope DNA Vaccines.利用HLA-A2.1转基因兔模型筛选和鉴定新型HLA-A2.1限制性表位DNA疫苗。
J Vaccines Vaccin. 2010 Aug 20;1(1). doi: 10.4172/2157-7560.1000101.
4
The emergence of immunomodulation: combinatorial immunochemotherapy opportunities for the next decade.免疫调节的出现：未来十年的组合免疫化疗机会。
Gynecol Oncol. 2010 Feb;116(2):222-33. doi: 10.1016/j.ygyno.2009.11.001. Epub 2009 Dec 2.
5
Protective immunity with an E1 multivalent epitope DNA vaccine against cottontail rabbit papillomavirus (CRPV) infection in an HLA-A2.1 transgenic rabbit model.在HLA - A2.1转基因兔模型中，用E1多价表位DNA疫苗对棉尾兔乳头瘤病毒（CRPV）感染的保护性免疫。
Vaccine. 2008 Feb 6;26(6):809-16. doi: 10.1016/j.vaccine.2007.11.081. Epub 2007 Dec 26.
6
Vesicular stomatitis virus-based therapeutic vaccination targeted to the E1, E2, E6, and E7 proteins of cottontail rabbit papillomavirus.以水泡性口炎病毒为基础的治疗性疫苗，靶向棉尾兔乳头瘤病毒的E1、E2、E6和E7蛋白。
J Virol. 2007 Jun;81(11):5749-58. doi: 10.1128/JVI.02835-06. Epub 2007 Mar 28.
7
Vaccination of rabbits with an adenovirus vector expressing the papillomavirus E2 protein leads to clearance of papillomas and infection.用表达乳头瘤病毒E2蛋白的腺病毒载体对兔子进行疫苗接种可导致乳头瘤和感染的清除。
J Virol. 2004 Jan;78(1):116-23. doi: 10.1128/jvi.78.1.116-123.2004.
8
Correlates of IL-10 and IL-12 concentrations in cervical secretions.宫颈分泌物中白细胞介素-10和白细胞介素-12浓度的相关因素
J Clin Immunol. 2003 May;23(3):175-83. doi: 10.1023/a:1023305827971.
9
Life cycle heterogeneity in animal models of human papillomavirus-associated disease.人乳头瘤病毒相关疾病动物模型中的生命周期异质性
J Virol. 2002 Oct;76(20):10401-16. doi: 10.1128/jvi.76.20.10401-10416.2002.
10
Intracutaneous DNA vaccination with the E8 gene of cottontail rabbit papillomavirus induces protective immunity against virus challenge in rabbits.用棉尾兔乳头瘤病毒E8基因进行皮内DNA疫苗接种可诱导兔产生针对病毒攻击的保护性免疫。
J Virol. 2002 Jul;76(13):6453-9. doi: 10.1128/jvi.76.13.6453-6459.2002.
本文引用的文献
1
STUDIES ON THE MECHANISM RESPONSIBLE FOR THE SPONTANEOUS REGRESSION OF THE SHOPE RABBIT PAPILLOMA.关于肖普兔乳头瘤自发消退机制的研究。
Cancer Res. 1963 Oct;23:1593-9.
2
3
A vaccination procedure which increases the frequency of regressions of Shope papillomas of rabbits.一种能提高兔肖普乳头瘤消退频率的疫苗接种程序。
Nature. 1962 Jan 20;193:288-9. doi: 10.1038/193288a0.
4
The pathogenesis of the rabbit papilloma-to-carcinoma sequence.兔乳头瘤至癌演变过程的发病机制。
Ann N Y Acad Sci. 1952 Jul 10;54(6):1126-40. doi: 10.1111/j.1749-6632.1952.tb39983.x.
5
Prophylactic and therapeutic vaccination against a mucosal papillomavirus.针对黏膜乳头瘤病毒的预防性和治疗性疫苗接种。
J Gen Virol. 1993 Jun;74 ( Pt 6):945-53. doi: 10.1099/0022-1317-74-6-945.
6
Delayed-type hypersensitivity response to the human papillomavirus type 16 E7 protein in a mouse model.小鼠模型中对人乳头瘤病毒16型E7蛋白的迟发型超敏反应
J Gen Virol. 1993 Feb;74 ( Pt 2):239-45. doi: 10.1099/0022-1317-74-2-239.
7
Latent infection induced with cottontail rabbit papillomavirus. A model for human papillomavirus latency.棉尾兔乳头瘤病毒诱导的潜伏感染。人乳头瘤病毒潜伏的一种模型。
Am J Pathol. 1994 Jun;144(6):1167-71.
8
Changes in RNA expression pattern during the malignant progression of cottontail rabbit papillomavirus-induced tumors in rabbits.棉尾兔乳头瘤病毒诱导的兔肿瘤恶性进展过程中RNA表达模式的变化。
J Virol. 1994 Jun;68(6):3620-30. doi: 10.1128/JVI.68.6.3620-3630.1994.
9
Antibody and cytotoxic T-cell responses to soluble hepatitis B virus (HBV) S antigen in mice: implication for the pathogenesis of HBV-induced hepatitis.小鼠对可溶性乙型肝炎病毒（HBV）S抗原的抗体和细胞毒性T细胞反应：对HBV诱导的肝炎发病机制的启示。
J Virol. 1994 Mar;68(3):1418-25. doi: 10.1128/JVI.68.3.1418-1425.1994.
10
Analysis of the nucleotide sequence variation of the antigen-binding domain of DR alpha and DQ alpha molecules as related to the evolution of papillomavirus-induced warts in rabbits.
J Invest Dermatol. 1994 Sep;103(3):376-80. doi: 10.1111/1523-1747.ep12395285.
Zotero 插件