Campo M S, Grindlay G J, O'Neil B W, Chandrachud L M, McGarvie G M, Jarrett W F
Beatson Institute for Cancer Research, CRC Beatson Laboratories, Glasgow.
J Gen Virol. 1993 Jun;74 ( Pt 6):945-53. doi: 10.1099/0022-1317-74-6-945.
Papillomaviruses are ubiquitous DNA viruses affecting humans and animals and causing a variety of tumours of mucosal and cutaneous epithelia. Some of these lesions, particularly those affecting mucosal epithelia, can progress to squamous cell carcinomas. Prevention or cure of viral infection would ultimately lead to a decrease in the incidence of papillomavirus-associated cancers. Using recombinant proteins, we have developed prophylactic and therapeutic vaccines against bovine papillomavirus type 4, a mucosal papillomavirus implicated in cancer of the alimentary canal in cattle; similar possibilities exist for the human mucosal papillomaviruses.
乳头瘤病毒是一种普遍存在的DNA病毒，可感染人类和动物，并引发各种黏膜和皮肤上皮肿瘤。其中一些病变，尤其是那些影响黏膜上皮的病变，可能会发展为鳞状细胞癌。预防或治愈病毒感染最终将导致乳头瘤病毒相关癌症的发病率下降。我们利用重组蛋白开发了针对4型牛乳头瘤病毒的预防性和治疗性疫苗，4型牛乳头瘤病毒是一种与牛消化道癌症有关的黏膜乳头瘤病毒；人类黏膜乳头瘤病毒也有类似的可能性。
